COLOR REACTION'S AND SPLIT PRODUCTS 107 



is, in proportion to body weight, twenty-five 

 (25) times more toxic for the guinea-pig than 

 the rabbit. 



4. Tissue cellular protein poison hastens the 

 clotting of the blood of the guinea-pig, rabbit, 

 and dog in vivo. The protein poison prepared 

 from casein differs from these in that it either 

 retards or prevents entirely the clotting of dog's 

 blood. 



5. Witte's peptone does not prevent the clot- 

 ting of rabbit's blood in vitro. 



6. The in vitro experiments here reported 

 show that all the protein poisons tested inhibit 

 the clotting of blood from the guinea-pig, rab- 

 bit and dog, in certain percentages. 



THE COLOR EEACTIONS OF PEOTEINS 

 AND THEIR SPLIT PRODUCTS. 



Emerson and Chambers* have made a com- 

 parative study of the protein color reactions 

 on the original proteins and their poisonous 

 and nonpoisonous split products. These stud- 

 ies give some conception of the lines along 

 which the cleavage of the protein develops. 

 The conclusions are stated as follows: 



1. The proteins and their split products, the 



*Emerson and Chambers: Jour. Lab. and Clin. Med., i, 692. 



