ii UNCLASSIFED DISSOCIATION-PRODUCTS 85 



8. Skatosin, C 10 H 16 N 2 2 , is a base which Baum 1 and Swain 2 

 isolated from the autodigested pancreas ; on being melted with 

 alkalies it yields skatol, and hence its name. It is not identical with 

 tryptophane, as the latter does not possess strongly basic properties. 

 Skatosin hydrochloride contains 3 molecules of hydrochloric acid, 

 which fact is still unaccounted for. It is' a yellowish- white substance 

 which melts and simultaneously decomposes between 345 and 355. 

 Langstein 3 has isolated from serum-albumin, after prolonged peptic 

 digestion, a body which in its properties resembles skatosin. 



9. Lysatinin, C 6 H 13 N 3 2 . Along with lysin, it was isolated by 

 Drechsel, 4 from casein as one of the first basic substances, but since 

 Hedin 5 prepared arginin from it, it is generally supposed not to be a 

 chemical individual but a mixture of lysin and arginin (see above, pp. 

 37 and 38), or a double salt of these bases crystallising in definite 

 proportions. Siegfried 6 states, however, that he has tried unsuccess- 

 fully to prepare lysin or arginin from lysatinin, and therefore believes 

 lysatinin to be a definite chemical compound. As it is only formed 

 on dissociating casein with hydrochloric acid and zinc chloride, but 

 not if sulphuric acid is used, Siegfried believes lysatinin to be perhaps 

 another base which has become secondarily transformed. 



10. Leucin-imide, C 12 H 22 N 2 2 



C 4 H 9 CH NH CO 



CO NH CH C 4 H 9 , 



is 3'6-di-isobutyl-2'5-di-acipiperazin (butyl alcohol = CH 3 (CH 2 ) 3 OH). 

 Bitthausen, 7 Cohn, 8 and Abderhalden 9 showed its presence after 

 dissociating proteids with acids, and Salaskin 10 after peptic digestion, 

 but there can be but little doubt that it is formed secondarily. 9 

 Curtius n and E. Fischer 12 have pointed out that the derivatives of 

 the amino- acids have a tendency to ring -formation, and that they 



1 F. Baum, Hofmeister's Beitrdge, 3. 439 (1903). 



2 K. E. Swain, ibid. 3. 442 (1903). 



3 L. Langstein, ibid. 1. 518 (1901). 



4 E. Drechsel, Arch. f. (Anat. u.) Physiol. 1891, p. 248. 



5 S. G. Hedin, Zeitschr. /. physiol. Chem. 21. 297 (1895). 



6 M. Siegfried, ibid. 35. 192 (1902). 



7 H. Bitthausen, Eiweisskorper der Getreidearten, Bonn, 1872 ; Her. d. deutsch. chem. 

 Ges. 29. II. 2109 (1896). 



8 E. Cohn, Zeitschr. f. physiol. Chem. 29. 283 (1900). 



9 E. Abderhalden, ibid. 37. 484 (1903). 



10 S. Salaskin, ibid. 3^. 592 (1901). 



11 T. Curtius and F. Gobel, Journ. f. prakt. Chem. (2), 37. 150 (1888). 



12 E. Fischer, Ber. d. deutsch. chem. Ges. 34. J. 383 (1903). 



