in ON THE SYNTHESIS OF ALBUMINS 123 



An attempt made by Curtius and Lenhard to build up long chains 

 in which the carbaminic acid radical (NHCO), ' was to play the same 

 part as the glycyl-radical (NHCH 2 CO) ' failed, because the carbaminic 

 acid was decomposed into ammonia and carbon-dioxide, but phenyl- 

 carbamindiglycylglycin was obtained : 



C 6 H 5 NHCO . (NHCH 2 CO) 2 . NHCH 2 . COOH. 



Some dissodation-pi'oduds of hippurazide-compounds. 



If azides of mono-amino-acids are treated with ammonia or anilin 

 or alcohol, according to circumstances, either normal saponification or 

 transformation into urea-derivatives supervenes, 1 but on treating the 

 azides of dibasic acids both phenomena may be observed in the same 

 molecule, there being obtained compounds which are one half acid- 

 amides and one half urea-derivatives. On hydrolysing these compounds 

 the amino-acid chains are readily demonstrated. 



Hippenyl-urethane, C 6 H 5 CONHCH 2 NH . CO . OC 2 H 5 , formed from 

 hippurazide and alcohol, on being hydrolysed yields benzoic acid, 

 ammonia, formaldehyde, carbon-dioxide, and alkohol : 



C 6 H 5 CO . NHCH 2 . NH . CO . OC 2 H 5 + 3H 2 O = 

 C 6 H 2 COOH + 2NH 3 + CHOH + C0 2 + C 2 H 5 OH. 



The reaction leads thus from glycocoll to formaldehyde. 



Analogously hippuryl-alanin-azide + aniline form the urea deriva- 

 tive : C 6 H 5 CO . NHCH 2 CO NHCH(CH 3 )NH . CO . NHC 6 H 5 and this 

 on hydrolysis takes up three molecules of water, and is converted into 

 C 6 H 5 CO . NHCH 2 COOH + 2NH 3 + CH 3 CHO + CO 2 + C 6 H 5 NH 2 



Hippuric acid + ammonia + acetaldehyde + carbonic + anilin. 



By the action of anilin on hippuryl-aspartic-acid-azide is formed 

 a compound which is half anilid and half carbanilid : 



C 6 H 5 CO . NHCH 2 CO . NHCHCO . NHC 6 H 5 



H 2 .NHCONH.C 6 H 5 . 



On hydrolising this compound besides hippuric acid, aniline and 

 C0 2 , also a-/S-diamino-propionic acid is formed : 



C 6 H 5 CO . NHCH 2 CO . NHCHCO . NHC 6 H 5 



CH 2 NH . CO . NC 6 H 5 H + 3H2 



C 6 H 5 CO . NHCH 2 COOH + NH 2 CHCOOH 



6H 2 NH 2 +2C 6 H 5 NH 2 + C0 2 ; 



1 Th. Cxirtius, Journ. /. prakt. Chem. [2] 50. 292 (1894). 



