v KYRINS 201 



sulpho-compound have been examined. Kyrin is also obtained from 

 glutin anti-peptone, and its importance as the basic 'nucleus of the 

 proteid' has been discussed already in connection with the anti-group, on 

 p. 195 ; there it was also pointed out that Kossel's doctrine as to the 

 existence of a basic nucleus is supported by the discovery of kyrin. 

 The latter gives the biuret-reaction ; on being dissociated with acids 

 it yields lysin, arginin, glycocoll, and glutaminic acid. As two-thirds 

 of the nitrogen is basic, and of this again two-thirds is contained 

 in arginin, the composition seems to be as follows : 



1 molecule arginin . . . C 6 H 14 N 4 2 



1 lysin . . . C 6 H 14 N 2 2 



1 glutaminic acid . C 5 H 9 N 4 



2 glycocoll . . C 4 H 10 N 2 4 



minus 4 molecules of water . H 8 4 



Gluto-kyrin .... C 21 H 39 N 9 8 



Siegfried l has prepared a quite similar basic nucleus, the caseino- 

 kyrin, from casein. Its nitrogen is in the form of basic -nitrogen 

 (arginin and lysin) to the extent of 84-85 per cent, while the amino- 

 acid-nitrogen (glutaminic acid) amounts from 15 to 16 per cent. 



This base has the formula C 23 H 47 "N' 9 8 . 



Hydrolytic dissociation sets free arginin, lysin, and glutaminic acid, 

 but no histidin or ammonia. Siegfried assigns to caseino-kyrin the 

 formula 



1 molecule arginin . . C 6 H 14 N 4 2 



2 lysin . . C 12 H 28 N 4 4 

 1 ,, glutaminic acid . C 5 H 9 N 4 



minus 2 molecules of water . H 4 2 



Caseino-kyrin . . . . C^tl^NgOg 



V. ALBUMOSES PRODUCED BY THE ACTION OF ALKALIES 



Maas 2 has dissociated albumins with dilute alkalies. He found 

 alkali-albuminates and albumoses, but no peptones, as the latter were 

 evidently at once broken up still further. An alkali-albumose pre- 

 pared from egg -albumin was specially investigated, but similar 

 1 M. Siegfried, Zeitschr.f.physiol Chem. 43. 46 (1 904). 2 0. Maas, ibid. 30. 61 (1900). 



