v ATMID-ALBUMOSES AND CARNIC ACID 203 



By prolonged heating to only 130, Salkowski prepared from meat 

 and fibrin products essentially resembling those of Neumeister ; they 

 differ in giving a well-marked Millon's reaction, and being more readily 

 digested than are Neumeister's preparations. Salkowski believes his 

 substance to be the ammonium -salt of an albumose, and not an 

 albumose. 



The papayotin-albumoses closely resemble the atmid-albumoses, 

 according to Neumeister. 1 



Somatose is an atmid-albumose. 



Carnic or Sarctic Acid 



Kemmerich's meat-extract contains, as first stated by Kemmerich 2 

 and confirmed by Mays, 3 albumoses and peptones, which are probably 

 formed by a transformation of the not readily coagulable muscle- 

 albumins. There are found, however, in muscle also pre-formed non- 

 coagulable albumins. According to Mays, one of these substances is 

 carnic acid, which Siegfried 4 and his pupils 5 prepared from Kem- 

 merich's meat extract by removing all phosphates, and then precipitat- 

 ing with ferric chloride. Carnic acid has the same composition and 

 the same properties as has an anti-peptone. Its formula is 



C 10 H 16 N 3 5 . 



Adopting this formula, it is mono-basic. It gives an intense, red biuret- 

 reaction, but no other colour-tests ; it is precipitated by alkaloidal 

 reagents. It is not salted out by ammonium sulphate. Its disintegra- 

 tion-products are ammonia, carbonic acid, lysin, arginin, leucin, and 

 succinic acid. Of still greater importance are its two derivatives, 

 phosphocarnic acid and carniferrin. The phosphocarnic acid contains 

 large amounts of phosphorus, and is, according to Siegfried, a nucleone, 

 while carniferrin contains iron as well as phosphorus. Carniferrin is 

 found in small amounts in urine, in muscles, and in cow's milk ; in 



1 R. Neumeister, Deutsche medizinische Wochenschrift, 1893, NT. 36 and 46. 



2 E. Kemmerich, ibid. 18. 409 (1893). 



3 K. Mays, Zeitschr. f. Biol. 34. 268 (1896). 



4 M. Siegfried, ' Uber Fleischsaure, ' Arch. f. (Anat. u.) Physiol., 1894, p. 401; 

 'Zur Kenntnis der Phosphorfleischsaure,' Zeitschr. /. physiol. Chem. 21. 360 (1895), 

 22. 575 (1897) ; 'Uber Antipepton,' I. ibid. 27- 335 (1899), 28. 524 (1899). 



5 W. S. Hall, 'Resorption des Karniferrins,' Archivfiir (Anat. und) Physiol., 1894, 

 455 ; C. W. Rockwood, 'Sarctic Acid in Urine,' ibid. 1895, p. 1 ; P. Balke and Ide, 

 'Quantitative Estimation of Phosphosarctic Acid,' Zeitschr. f. physiol. Chem. 21. 380 

 (1895); F. R. Kriiger, ibid. 22. 45 (1896); P. Balke, ' Dissociation - products of 

 Carniferriu,' ibid. 22. 248 (1896) ; Martin Miiller, 'The Amount of Nucleon in Human 

 Muscle,' ibid. 22. 561 (1897) ; K. Wittmaack, ' Nucleon -content of Milk,' ibid. 22. 567 

 (1897) ; R. T. Kriiger, ibid. 28. 535 (1899) ; I. J. R. Macleod, ibid. 28. 535 (1899). 



