v PHYSIOLOGY OF ALBUMOSES AND PEPTONES 205 



thereby it is possible to exclude all tissue ferments. The objection to 

 gastric juice obtained by Pawlow's method is, however, that it does 

 not represent both cardiac and pyloric secretions, and it may for this 

 reason be less active than is the pepsin secreted from the whole 

 stomach. The first to point out that peptic digestion liberates mono- 

 amirio-acids, such as leucin-imide, was Salaskin, 1 and later Salaskin and 

 Kowalewsky. 2 Lawrow 3 obtained from gelatine 35*2 per cent 

 of the nitrogen as mono-amino-nitrogen, on dissolving 400 grammes of 

 commercial gelatine in 4 litres of 0'5 per cent HC1, and then adding 

 900 ccm. of dog's gastric juice, obtained by Pawlow's method, and an 

 excess of chloroform. 



A stomach which was allowed to autodigest itself in the presence 

 of 0-5 per cent HC1, gave rise to exactly the same products as other 

 albumins did on being acted upon by gastric juice obtained by Pawlow's 

 method. 



While according to Salaskin, Kowalewsky, and Lawrow, mono- 

 amino-acids are always formed by peptic digestion, Abderhalden and 

 Rostoski, 4 on the other hand, failed to get any mono-amino-acids apart 

 from traces of tyrosin, when they acted on edestin prepared from 

 cotton-seed. 



While native albumins which have escaped the action of peptic 

 digestion may be absorbed as such according to Rosenberg and 

 Oppenheimer, 5 it is quite different with albumoses and peptones, for 

 these, according to Neumeister, 6 are found nowhere in the animal body 

 except in the alimentary canal. The contradictory statements of other 

 authors are to be explained on the ground of the great difficulty met with 

 in completely separating out all albumins ; traces of albumin which have 

 escaped coagulation have been taken for pre-existing albumoses. The 

 more recent statements of Embden and Knoop 7 and Langsteiri 8 as to the 

 occurrence of albumoses in blood do also not appear convincing. Under 

 pathological conditions, however, as during pus-formation, 9 during the 

 absorption of exudations 10 and similar processes, albumoses do occur in 

 the animal body. Sometimes they are formed rapidly and abundantly 



1 S. Salaskin, Zeitschr.f. physiol. Ghem. 32. 592 (1901). 



2 S. Salaskin and K. Kowalewsky, ibid. 38. 567 (1903). 



3 D. Lawrow, ibid. 44. 447 (1905). 



4 E. Abderhalden and 0. Rostoski, ibid. 44. 265 (1905). 



5 S. Rosenberg and C. Oppenheimer, Hofmeister's Beitrage, 5. 412 (1904). 

 (i R. Neumeister, ibid. 24. 272 (1888). 



7 G. Embden and F. Knoop, ibid. 3. 120 (1902). 



8 L. Langstein, ibid. 3. 373 (1902). 



9 F. Hofmeister, Zeitschr.f. physiol. Cliem. 4. 268 (1880). 



10 Fr. Miiller, Verh. der Naturf. Ges. zu Basel, 13. 308 (1901) ; 0. Simon, Deutsch. 

 Arch. f. klin. Med. 70. 604 (1901). 



