v PHYSIOLOGY OF ALBUMOSES AND PEPTONES 207 



blood-pressure, but antipeptone, protones (i.e. digestion-products of the 

 protamins), histories, and arginin- carbonate, give negative results, 1 

 and the same holds good for the following substances : Glycine or 

 glycocoll, leucin, tyrosin, uracil, cytosin, indol, skatol, tryptophane, 

 xanthin, hypoxanthin, guanin, thymin, glycin-ethylester, a-pyrro- 

 lidin carboxylic acid, a-methyl-pyrrolidin carboxylic acid, arginin, 

 glutaminic acid, and glucothionic acids, according to Wolf. 2 Negative 

 results were also obtained by Halliburton 3 on injecting E. Fischer's 

 polypeptids : leucyl-glycin, leucyl- leucin, 'glycyl-asparagin, alanyl- 

 leucyl-glycin. The effect produced on respiration by the repeated 

 injection of peptone solutions, has been studied by Nolf. 4 



On injecting mono-amino acids into rabbits through a vein in the 

 ear, and examining the urine by Pfaundler's method, 5 Stolte 6 found 

 alanin, aspartic acid, glutaminic acid and cystin (Blum) to increase the 

 amount of urea-N, and also that of the mono-amino acid N. Glycocoll 

 and leucin, if given in very large amounts, give rise to a transient 

 elimination of firmly bound N, and to a constant increase in the 

 urea-N. The aromatic mono-amino-acids, tyrosin and phenyl-alanin, 

 do not lead to an increase of urea formation in twenty-four hours. 



Glassner 7 has found that the amino-acids, leucin and lysin, are 

 only absorbed from the small and not from the large intestine, and 

 that normally albumoses, amino- and diamino-acids, are only met with 

 in the small intestine, while in the large intestine the dissociation- 

 products of the different amino-acids, as well as xanthin bases and 

 ammonia, are met with. See also pp. 108 to 114. 



1 W. H. Thompson, Zeitschr. f. physiol. Chem. 29. 1 (1900), and 32. 137 (1905). 



2 C. G. L. Wolf, Journ. of Physiol. 32. 171 (1905). 



3 W. D. Halliburton, ibid. p. 174. 



4 P. Nolf, Arch, de Biol. 2O. 101 (1904). 



5 Pfaundler, ZentralU.f. Physiol. 14. 538 (1900). 



6 K. Stolte, Hofmeister 's Beitrdge, 5. 15 (1904). 



7 K. Glassner, Zeitschr. f. klin. Med. 52. p. 386. 



