THE ALBUMINS PROPER 



355 



from the blood of other animals. Wichmann 1 has studied the 

 crystallography of serum-albumin. Giirber was of the opinion that the 

 once generally accepted view, namely, that the serum - albumins of 

 different animals are similar, could not be maintained because of 

 crystallographic differences, but his pupils Meyer, Wichmann, 1 and 

 Schulz 2 have disproved his objections. The endeavour of Oppenheimer 3 

 to split up serum-albumin into several fractions by means of ammonium 

 sulphate has not led to definite results, and therefore, at present, serum- 

 albumin must be regarded to be a uniform and specific compound. 

 The great agreement between the analyses of even amorphous prepara- 

 tions also points to there being only one serum-albumin. 



From their analyses Hofmeister and Kurajeff 11 calculate the 

 formula 



and the molecular weight as 10,166. 



The coagulation-temperature has been determined by FredeYicq 12 

 as 67, and with it the figures of Starke, 8 Sebelien, 13 and Michel 4 agree 

 well. The specific rotation is - 57 to - 64, according to Fredericq, 14 



* A. Wichmann, Zeitschr. f. physiol. Chem. 27. 575 (1899). 



2 F. N. Schulz, Kristallisation von Eiweisssto/en, Jena, G. Fischer, 1901. 



3 C. Oppenheimer, Archivf. (Anal, u.) Physiol. 1903, p. 201. 



4 A. Michel, Wiirzburger phys.-med. Ges. N.F. 29. 117 (1895). 



5 E. Abderhalden, Zeitschr. f. physiol. Chem. 37. 495 (1903). 



6 Middeldorf, Wurzburger phys.-m*d. Ges. N.F. 31. (1897). 



7 F. N. Schulz, Zeitschr. f. physiol. C/iem. 25. 16 (1898). 



8 K. V. Starke, Maltfs Jahresbericht, 11. 17 (1881). 



9 K. A. Mcirner, Zeitschr. f. physiol. Chem. 34. 207 (1901). 



10 F. Blum, OKd. 28. 288 (1899). 



11 D. Kurajeff, ibid. 26. 462 (1899). 



12 L. Fredericq, Bull, de I'Acad. r. de Belgique, 2 ser. 64. 7 (1877) ; Ann. de Soc. 

 d. medecine de Gent, 1877 (reprint). 



13 J. Sebelien, Zeitschr. f. physiol. Chem. 9. 445 (1885). 



14 L. Fredericq, Arch, de Biolog. I. 457 (1880). 



