ix LACT-ALBUMIN AND THE GLOBULINS 361 



investigated for the first time by Sebelien l in Hammarsten's laboratory. 

 Wichmann 2 succeeded in preparing crystalline lact-albumin by Giirber's 

 method ; the crystals resemble those of the other albumins. The data 

 at present are insufficient for drawing any conclusion as to the inter- 

 relationship of lact-albumin and serum-albumin. 



According to Sebelien lact-albumen has the percentage composition 



^52-19 H 7 . 18 ^15-77 S r73 P' 



Other albumins are not known. The albumin found by C. T. 

 Morner 3 in the eye and by Kiihne 4 in muscle are derived from traces 

 of blood or lymph (v. Fiirth). 5 No albumins could be found in the 

 liver and in the thyroid by P16sz, 6 Oswald, 7 and others. The so- 

 called yolk-albumin, from which Mayer and Neuberg prepared gluco- 

 samin, if judged by its solubility, is not an albumin but rather a vitelline 

 (see p. 405). Infusoria (Sosnowski 8 ) and mussels (Cohnheim) also 

 contain no albumin. H. Buchner 9 states that he obtained ' albumin ' 

 from the juice pressed out of bacteria, but as he uses this term only to 

 show that the substance in question is not a proteid it may well be 

 & globulin. Palladin 10 mentions a vegetable albumin, without, 

 however, describing it more fully. 



II. THE GLOBULINS 



The formation of globulins by heating albumins is referred to 

 on pages 356 and 360. 



The globulins are simple coagulable albumins, which differ from 

 albumins in being insoluble in pure water and in dilute acids, but they 

 are soluble in dilute alkalies and in solutions of neutral salts (see p. 297). 

 They are, therefore, precipitated from salt-solutions by dilution with 

 water, and more completely by removing the salts through dialysis ; on 

 adding salts they pass again into solution. An explanation of their 

 physical behaviour has been offered by the author on p. 296. They 

 are also precipitated by acidifying their solutions and even by passing 

 ,a constant stream of C0 2 through the solution, and are rendered 



1 J. Sebelien, Zeitschr. f. physiol. Chem. 9. 445 (1885) (here the older literature). 



2 A. Wichmann, ibid. 27. 575 (1899). 



3 C. T. Morner, ibid. 18. 61 (1893). 



4 W. Kiihne, 'Archivf. Anat. u. Physiol. 1859, p. 748. 



5 0. v. Fiirth, Schmiedeberg s Arch. 36. 231 (1895). 



6 P. Plosz, Pflnger's Archiv, 7. 371 (1873). 



7 A. Oswald, Zeitschr. f. physiol. Chem. 27. 14 (1899). 



8 J. Sosnowski, ZentralU. /. Physiol. 13. 267 (1899). 



9 H. Buchner, Miinchener medizin. Wochenschr. 1897, No. 12. 



10 W. Palladin, Zeitschr. f. Biolog. 31. 191 (1894). 



