364 



CHEMISTRY OF THE PROTEIDS 



CHAP. 



Serum-globulin forms a fraction of the albumins occurring in 

 blood-serum. According to Meyer, 1 Krieger, 2 and Joachim, 3 its per- 

 centage varies for different species of animals, and also for different 

 animals of the same species; the author believes its amount to be 

 determined by the alkalinity of its tissue-juices. Globulin passes into 

 the urine 4 during kidney-disease, into such transudations as the liquor 

 amnii, 5 and into the lymph. Ludwig and Salvioli 6 have further shown 

 that the ratio of the albumin to the globulin is the same in lymph as 

 in blood. 



It has not been prepared in a crystalline form. 



Its analysis has yielded these results : 



The coagulation-temperature has been found to be the same by all 

 investigators. 12 It amounts to 75, and is fairly independent of the 

 amount of salt present. According to Fredericq 13 



a D = -47-8. 



The dissociation-products are enumerated on p. 70, No. 3. The 

 high glycocoll-content is especially remarkable, and this is character- 

 istic of the antigroup. For the same reason it is very resistant to 

 ferments, as pointed out by Umber, 14 E. Fischer and Abderhalden, 15 



1 G. Meyer, Med. Dissert., Wiirzburg, 1896. 



2 H. Krieger, Dissert., Strassburg, 1899. 



3 J. Joachim, Wien. klin. Wochenschr. 1902, No. 21. 



4 J. Pohl, Arch. f. experiment. Pathol. u. Pharm. 20. 426 (1886). 



5 Th. Weyl, Arch.f. (Anat. u.) PhysioL 1876, p. 543. 



6 G. Salvioli, ibid. 1881, p. 269. 



7 0. Hammarsten, 'tJber das Fibrinogen,' Pfltiger's Arch. f. d. ges. PhysioL 22. 

 431 (1880). 



8 W. Hausmann, Zeitschr. f. physiol. CJiem. 27. 95 (1899). 



9 F. Blum, ibid. 28. 288 (1899). 



10 F. N. Schulz, ibid. 25. 16 (1898). 



11 K. A. H. Morner, ibid. 34. 207 (1901). 



12 0. Hammarsten, Pflilgers Arch.f. d. ges. Physiol. 17. 413 ; 18. 38 (1878) ; and 

 in Zeitschr. f. physiol. Chem. 8. 467 (1884) ; and in Ergebnisse der Physiologic von 

 Asher-Spiro, 1. I. 330 (1902) ; L. Fredericq, Ann. de la Soc. de Med. de Gent, 1877 ; 

 Th. Weyl, see No. 4, last page. 



13 L. Fredericq, Ann. de la Soc. de Med. de Gent, 1877 ; Th. Weyl, see No. 4, last 

 page. 14 F. Umber, Zeitschr. f. physiol. Ohem. 25. 258 (1898). 



16 E. Fischer and E. Abderhalden, ibid. 39. 81 (1903). 



