ix THE GLOBULINS 369 



or hetero-globulose. The nature of this substance is therefore as yet 

 doubtful. It crystallised from the very strongly acid urine, which con- 

 tained relatively little salt, after a few hours or only after some weeks 

 in the shape of broad needles belonging to the rhombic system. 

 Its analysis yielded :.- 



1'26 23' 93- 



The coagulation-temperature was between 58 and 59, but coagu- 

 lation was never very complete. Its reactions were the same as those 

 of globulin, except that it was completely salted out by sodium 

 chloride. 



This globulin is probably identical with Bence Jones' albumin. 



7. Bence Jones' Albumin 



This substance used to be taken for an albumose, but is a native 

 albumin according to more recent accounts. It is found in the urine. 



Bence Jones 1 observed in 1848 the elimination of a substance 

 which in 1869 was rediscovered and described by Kiihne. 2 Sub- 

 sequently observations have been made by Matthes, 3 Ellinger, 4 Magnus- 

 Levy, 5 Jochmann and Schumm, Grutterinck and de Graaff, 7 and 

 by Parkes. 8 In all cases sufficiently carefully examined, the patients 

 were suffering from sarcoma of the marrow, and only in the case of 

 Jochmann and Schumm from a true osteomalacia. The patients 

 excreted Bence Jones' albumin in abundant, and in some cases even 

 very abundant amounts, either during the whole period of the disease 

 or at least during some time of it. 



Ellinger has succeeded in obtaining this body from the diseased 

 bone -marrow, although only in very small quantities. There is 

 nothing else known as to its origin. 



The most accurate description of it we owe to Magnus-Levy ; he, 

 as well as Grutterinck and de Graaf, succeeded in obtaining Bence 

 Jones' albumin in crystals. Complete analyses have not been made. 



1 Bence Jones, Philosophical Transact. 1848, I. p. 55. 



2 W. Kiihne, Zeitschr. f. Biolog. 19. 209 (1883). 



3 M. Matthes, Verhandl. d. 14. Kongresses f. inn. Medizin, Wiesbaden, 1896, p. 

 476. 



4 A. Ellinger, Deutsch. Arch. f. Jdin. Medizin, 62. 255 (1899) (here a complete 

 account of the literature). 



5 A. Magnus-Levy, Zeitschr. f. physiol. Ohem. 30. 200 (1900). 



6 G. Jochmann and O. Schumm, Munch, med. Wochenschr. 1901, p. 1340. 



7 A. Grutterinck and C. J. de Graaff, Zeitschr. f. physiol. Chem. 34. 393 (1901). 



8 Weber F. Parkes, Journ. of Pathol. and Bacterial. Q. 172 (1904) (here is given 

 a complete account of all the clinical cases). 



2 B 



