x THE NUCLEO-PROTEIDS 463 



9. Nudeo-Proteids of Muscle and of other Organs 



Pekelharing T and Kossel 2 found in adult muscle only traces of 

 nucleo-proteid, while in embryonic muscle it is much more abundant. 2 

 It stands perhaps in some relation to Siegfried's sarctic or carnic acid 

 (see p. 203). The inosinic acid of Haiser, 3 mentioned on p. 442, is a 

 nucleic acid contained in muscle-extracts. As nucleo-proteids are 

 present in all nuclei, they are found, of course, in all the organs of 

 the body. Dissociation-products of nucleic acids have already been 

 mentioned on p. 440. Acid-albumins containing phosphorus and 

 usually also iron have been found, amongst others, by Plosz, 4 Zaleski, 5 

 and Schmiedeberg [* ferratin '] 6 in the liver, by Halliburton 7 and his 

 pupils in many organs, by Hammarsten 8 in the liver of the snail 

 Helix pomatia, by Sosnowski 9 in amoabae, by Petry 10 in cellular 

 tumours, and by Pekelharing 11 in the blood. Pekelharing believes 

 that this nucleo-proteid plays a part in blood-coagulation. Whether 

 all the substances just mentioned are really nucleo-proteids is by no 

 means quite certain, for they may be nucleo-albumins of the cell-plasm 

 (compare p. 406). 



10. The Nucleo-Proteids of Plants 



Yeast. One of the earliest discovered and best known nucleic 

 acids is that of the yeast, first isolated by Kossel. 12 Its composition- 

 and dissociation-products are given on pp. 440, 442. Kossel also 

 prepared a nuclein. In addition to it there occurs in yeast the 

 plasminic acid (see p. 447). 



1 C. A. Pekelharing, Zeitschr. f. physwl. Chem. 22. 245 (1896). 



2 A. Kossel, ibid. 7. 7 (1882). 



8 F. Haiser, Monatsh.f. Chem. 16. 190 (1895). 



4 P. Plosz, Pflugers Archiv f. d. ges. Physiol. 7- 371 (1873). 



5 S. Zaleski, Zeitschr. f. physiol. Chem. 1O. 453 (1886). 



6 0. Schmiedeberg, 'Ferratin,' Schmiedeberg 's Archiv f. experiment. Path. u. Pharm. 

 33. 1 (1893). 



7 W. D. Halliburton, 'Blood Proteids,' Journ. of Phys. 7. 319(1886); 'Fibrin- 

 ferment,' ibid. 9. 224 (1888) ; Halliburton and W. M. Friend, ' Stromata of the Bed 

 Corpuscles,' ibid. 10. 532 (1889) ; Halliburton, ' Nervous Tissues,' ibid. 15. 90 (1894) ; 

 Fr. Gourlay, 'Thyroid and Spleen,' ibid. 16. 23 (1894) ; J. R. Forrest, 'Red Marrow,' 

 ibid. 17. 174 (1894) ; W. D. Halliburton and Gregor Brodie, 'Nucleo-albumins and 

 Intravascular Coagulation,' ibid. 17. 135 (1894) ; W. D. Halliburton, 'Nucleo-proteids,' 

 ibid. 18. 304 (1895). 



8 0. Hammarsten, Pflilger's Archiv, 36. 373 (1885). 



9 J. Sosnowski, 'Chem. der Zelle,' Zentralbl. /. Physiol. 13. 267 (1899). 



10 E. Petry, Zeitschr. f. physiol. Chem. 27. 398 (1899). 



11 C. A. Pekelharing, Zentralbl. f. Physiol. 1895, p. 102. 



12 A. Kossel, Zeitschr. f. physiol. Chem. 3. 284 (1879); 4. 290 (1880); 7. 7 (1882). 

 See also under the dissociation -products. 



