92 Researches Regarding Cholera : The Blood. [part i. 



The liver contained a few extravasated spots of small size, and one about the 

 size of an almond beneath the peritoneum close to the gall-bladder. The spleen was 

 pale and bloodless. The kidneys appeared to be perfectly healthy. 



On opening the chest the pleural cavities were found free of fluid, and the mem- 

 branes, like the peritoneum, appeared perfectly healthy. The left lung was universally 

 mottled and congested. It was gorged with blood, and exhibited numerous small 

 spots of extravasation probably due to embolism, both superficially and throughout 

 its substance. The right lung showed numerous blackish spots towards the base, 

 but it was not universally congested like the right one. The pericardium was 

 healthy and contained no fluid. The surface of the heart, more especially of the left 

 ventricle, was covered with yellowish- white miliary spots, and small points of extra- 

 vasation. The cavities of the right side were extremely distended and full of soft, 

 black clot. 



The left ventricle contained a little fluid blood. 



Experiment XIII.— A healthy pup was put under chloroform, and three drachms 

 of choleraic material injected into the left femoral vein. The material consisted 

 of the fluid and sediment of an evacuation thoroughly shaken up, and was in an 

 active state of decomposition, the fluid being covered with a thick layer of bacteria, 

 and the sediment consisting in greater part of amorphous matter with a few persistent 

 red blood corpuscles. The injection was performed at 9 a.m., and the dog rapidly 

 came out of the influence of the chloroform. It died at midnight of the same day 

 without having shown any choleraic symptoms. 



A post-mortem examination was performed at 8 a.m. of the following morning, 

 23 hours after the operation. The post-Tnortem rigidity was well marked. There 

 was no evidence of inflammatory action around the wound in the thigh, which 

 appeared clean and healthy. On opening the abdomen, the cavity was found to 

 be free of fluid, the surface of the small intestines appeared slightly roughened, but 

 the parietal peritoneum was perfectly smooth and glistening, and there was no 

 evidence of inflammatory action present. The stomach was empty, and there were 

 a few ecchymosed spots on the mucous membrane. The duodenum appeared healthy 

 and contained a small quantity of bile-stained mucus. The mucous membrane was 

 perfectly free of injection throughout the upper portion of the jejunum, but towards 

 the lower extremity there was an ecchymosed patch three or four inches in length. 

 The ileum contained an abundance of mucus of a peculiar reddish hue. The large 

 intestine was also coated with abundant reddish mucus. 



The liver both on the surface and throughout its substance showed numerous small, 

 light coloured spots about the size of small shot. There were no inflammatory rings 

 around them ; after the specimen had been for twelve hours in a weak solution of 

 spirits, these spots, where on the surface, appeared slightly prominent ; but these 

 prominences disappeared on exposure to the air, and slight depressions replaced them, 



