PART I. j Injections of Organic Fluids into Peritoneal Cavity. 115 



etc., was injected into the right median-basilic vein. During the operation the 

 animal on two occasions ceased to breathe, but was each time speedily brought round 

 by artificial respiration. 



On, the following day the dog appeared to be perfectly well, and made his escape. 



ig) — The injecting materiel being seven days old. 



Experiment LXVII. — The dog referred to in the last experiment was caught 

 towards the evening of the day on which he made his escape, and on the following 

 morning placed under chloroform, when six drachms of the same fluid as had already 

 been introduced into its circulation, but now two days older, which had since remained 

 in an uncorked bottle, and was swarming with bacteria and vibriones, were injected 

 into the other median-basilic vein. 



During the four succeeding days the animal was closely watched, but he appeared 

 to have been in no way affected. 



Having been killed under chloroform, the viscera were carefully examined, but 

 no lesion detected anywhere, nor were there any signs of deposit in the lungs, liver 

 or other organs. Three preparations of blood were obtained from a thoracic vein, 

 and examined immediately, but not a single bacterium could be detected, nor were 

 there any developed in the cells, although under observation for a week. 



B.— Experiments on the Introduction of Choleraic and of other Organic solutions 

 into the Peritoneal cavity of animals. 



When the series of experiments on the effects of the introduction of solutions 

 of alvine discharges directly into the circulation, as recorded in the previous 

 pages, had been carried on for some time, we debated whether we should at once 

 proceed to repeat similar experiments with solutions of various other organic and of 

 inorganic substances, of acid, alkaline or neutral re-actions, or whether we should 

 continue to use the same infecting medium, varying the mode by which its 

 introduction into the system was effected. 



Having satisfied ourselves that putrefying matter introduced directly in the 

 blood, did very frequently exert as direct an action on the mucous membrane of the 

 small intestine, as, for example, mercury exerts on the mucous lining of the mouth 

 and on the salivary glands, or as atropia and calabar bean exert on the iris, we yet 

 felt convinced that the physiological phenomena evoked, and the pathological changes 

 induced, were not those of cholera, although appearing to present a certain though, 

 distant, relation to them. 



Although some remedial agents act in pretty much the same way, no matter 

 how introduced into the system, whether by the mouth, lungs or through the skin, 

 such as mercury and turpentine, the former increasing the salivary secretion, and the 



