1 72 



Researches Regarding Cholera : the Blood. 



[part I. 



TABLE XV icmii'MJued). 

 (<i)—The Choleraic material introduced being Fresh and Not subjected to Heat. 



Experiment 

 No. 



XXV 



XXVI 

 XXVII 



XXVIII 



XXIX 



XXX 



XXXI 



XXXII 



XXXIII 



XXXIV 



XXXV 



XXXVI 



Vein selected. 



Femoral. 



Saphena. 



Namber 



of 

 drachms 

 injected. 



Two 



Four 

 Four 



Four 



Total. ..15 



10 



Affected. 



Remarks. 



On the second day the temperature was 104°5, on the 

 3rd 103°, on the 4th 104°. when the animal died. 

 There were nosi^ecisdjjost-mortam appearances, except 

 in the liver, where numerous minute embolic patches 

 were visible and considei-able softening. Death evi- 

 dently due to embolism. 



Death in 7 hours. 



Death in (j hours. The same material used as in Exp. 

 XXVI. 



Death within seven hours. The animal had not been 

 purged, but the intestinal mucous membrane was 

 much congested and softened. 



Watched for 3 days ; killed under chloroform ; the 

 intestines were found to be quite healthy. 



The dog escaped on the second day, apparently in 

 excellent health. 



Ditto ditto ditto. 



Death within 1 2 hours, but no intestinal lesions present. 



At first there was considerable depression, but by the 

 next day the animal appeared tolerably well ; secre- 

 tion of urine abundant. 



S Counter-experiments were made with the fluid used in 

 these three experiments : seven dogs being under ob- 

 servation at the same time ; three having been treated 

 with unboiled material and four with the boiled. 



It will be observed that the principal phenomena induced by the toxic material 

 injected in these cases do not differ in their characters from those in which solutions 

 of other decomposing organic substances were introduced into the system, hsemorrhagic 

 gastro-enteritis being the leading feature recognized at i[)Ost-mortem examinations: 

 but we presume that some difficulty would be experienced in maintaining two opinions 

 with regard to the degree of toxic properties exerted by resorting to solutions of fresh 

 choleraic excreta, instead of to solutions of the same material derived from healthy 

 individuals. This will become still more evident when the data furnished by the 

 observation on heated choleraic material has been considered. 



Having on a former occasion discussed the nature of the lesions induced by the 

 introduction of these varying solutions of decomposing organic matter, we do not con- 

 sider it necessary to refer more definitely to them again, especially as the tables 

 contain an abstract of the salient post-mortem appearances. In the present instance 

 the question which we are desirous of testing is the degree of the toxic influence 

 exerted by the various solutions. 



It will be noted that in the foregoing two sets of experiments on choleraic 

 material the mortality is considerable ; in the case where heat was not employed 

 fifteen cases, yielding positive results in seven, or equal to 46-6 per cent. ; and in the 

 other set, out of thirteen animals, seven were affected, or nearly 54 per cent 

 average number affected, of both combined, being exactly 50 per cent. 



the 



