350 The Fungus Disease of Indiwi [part ii. 



oily fluid and abounding in roe-like particles. The posterior half resembled the 

 astragalus in condition generally, but contained several distinct cavities of considerable 

 size containing roe-like bodies. The remainder of the tarsal bones in the line of 

 section were almost entirely reduced to a softened, undifferentiated mass, riddled with 

 irregular cavities, and in which mere fragments of bone remained distinguishable, the 

 arch of the foot being entirely obliterated, and even the faintest indications of the 

 individual bones having been destroyed. The bases of the first phalanges of the toes 

 were the first recognisable osseous elements anteriorly, and even these were extremely 

 softened, opened out and oily in texture. Considering the extreme degree of the 

 degeneration, it was curious to observe how little the muscular tissue was affected, 

 the fibres being apparently unaltered, and presenting well-marked striae in almost 

 all the fragments which were subjected to microscopic examination. 



The fatty tissue throughout the entire foot was, however, very much altered 

 and degenerated. The subcutaneous fat showed various stages of degeneration with 

 great distinctness, the nests of fat-cells appearing in three distinct forms. («) The 

 normal loculi of connective tissue filled with apparently healthy fat, the capsule 

 containing the fat being seemingly unaltered, and the cells of the latter not being 

 readily separable from it. This condition was specially present towards the posterior 

 portion of the sole and behind the heel. (6) Loculi which presented pretty much 

 the same appearances as those in the previous form, but in which the contents 

 were more or less gelatinous, caseous, or waxy in appearance and consistence ; in 

 many cases, in fact, approaching more or less closely in their characters to those 

 presented by the ceruminous secretions of the ear. Two or more loculi were here 

 and there blended to a greater or less extent, or were almost united into a common 

 cavity of a larger size. The fatty contents were easily removed, leaving cavities 

 closely resembling those presently to be described, and only differing from them in 

 the less consistent nature of their lining membranes, (c) The cavities here were 

 enlarged, or rather the septa between the normal loculi were more or less completely 

 absorbed or thrust aside, in some cases having been entirely obliterated, and in 

 others persisting in a more or less fragmentary condition as threads or pillars of 

 connective tissue. These cavities were occupied by masses of circular, yellowish- white 

 grains or particles, like small seeds or ova, aggregated into masses of various sizes, 

 and evidently forming the roe-like bodies so constantly described as characteristic 

 of the discharges and tissues in this variety of the Madura-disease. 



The cavities in the deeper tissues of the foot were exactly similar in appearance 

 to those occupying the subcutaneous fat, and, like them, contained oily and fatty 

 matter in various forms, but principally in that of roe-like masses. Many of the 

 cavities, both superficial and deep, were quite isolated and unconnected with any 

 others, or with the surface, whilst others communicated freely with one another either 

 directly or by means of channels, and some of the more superficial also communicated 

 with the exterior in a similar fashion. In the latter case, the channels connected 



