366 The Fungus Disease of India. [part ii. 



covered with rough, warty nodules of hard bone extending along the entire length of 

 the shaft, the sclerosis being speciall}' marked towards the basal extremity of the bone. 

 Its under and inner surfaces were involved in the large cavity, and were more or less 

 scooped out. Like the second metatarsal this bone was also arched ; the phalanx of the 

 third toe was articulated on to the dorsal aspect of the corresponding metatarsal bone ; 

 the toe was consequently directed upwards. 



The third line of section was carried through the scaphoid, internal cuneiform, 

 and the longer bones of the great toe. There were other centres of disease here also. 

 A similar excavation had taken place in the metatarsal bone of this segment, and the 

 cavity was occupied by a dark globular mass. As in the other bones, the upper surface 

 of this was likewise curved, and the texture extremely dense, and its outer aspect 

 presented a hard nodulated surface. The bones of the phalanges were unaffected. 

 The scaphoid and cuneiform bones were reddish in the centre, as if from blood staining ; 

 the colour faded on exposure to air. Nothing peculiar could be detected in the 

 reddish substance when examined under a microscope. 



The tubercles along the affected metatarsal bones consisted of small, hollow, closed 

 cavities, which could be shaved from the surface of the bone. Some were rounded 

 elevations, like miniature limpet shells ; others were elongated and even tubular. Their 

 osseous walls were thin and very dense, and sometimes projecting spicules of bone were 

 given off from them internally. Their contents consisted mainly of fat with a mixture 

 of fibrous and connective-tissue corpuscles. 



The black material was microscopically identical with the similar substance in 

 other preparations — that is to say, it contained the usual filaments, but none of these 

 could be found in either the muscular, osseous, or fibrous tissues of the surrounding 

 parts, although carefully searched for by every known method. 



CHAPTER VII. 



PHYSICAL CHARACTERS AND RELATIONS TO SURROUNDING TISSUES OF THE BLACK MATERIAL 

 FREQUENTLY ASSOCIATED WITH THE FUNGUS-DISEASE OF INDIA. 



It must strike even the most casual reader, that the occurrence of these peculiar 

 lumps of black substance in the midst of the tissues referred to in the last chapter, 

 and especially in connection with Specimen V (page 365), is very remarkable; and 

 no one will wonder that it has been found very difficult, or rather impossible, 

 satisfactorily to account for their presence. It will have been observed that these 

 masses have been found, speaking generally, under three conditions : (1) in small 

 completely isolated cavities ; (2) in large cavities more or less accurately moulded 

 to their walls; (3) as broken fragmentary masses lodged in irregular cavities and 

 channels communicating freely with the surface^ 



