84 ENZYMES 



that Duccheschi and Almagia l found no appreciable difference in 

 the lipase content of normal and phosphorus-poisoned livers. 

 This question will be considered more fully in discussing fatty 

 metamorphosis. 



Fat necrosis resulting from the escape of pancreatic juice into 

 the peripancreatic tissues and abdominal cavity undoubtedly is 

 largely the result of lipase action. Flexner 2 found lipase 

 present in the foci of necrosis, and Opie demonstrated the 

 escape of lipase into the urine in pancreatitis with fat necrosis. 

 Wells (Joe. tit.) was unable to produce fat necrosis with extracts 

 of liver or blood-serum containing lipase, but found that pan- 

 creatic extracts rich in lipase produced fat necrosis, while the 

 same extracts were ineffective after the lipase had been destroyed 

 by the trypsin. (See a Fat Necrosis," Chap, xiii, for complete 

 consideration.) 



1 Arch. Ital. Biol., 1903 (39), 29. 

 3 Jour. Exper. Med., 1897 (2), 413. 



