448 METABOLIC ABNORMALITIES, AUTOINTOXICATION 



decreased by from ^ to in phosphorus poisoning. Carbaraates 

 do not seem to be present in recognizable amounts, and sugar 

 is also absent. 



In phosphorus poisoning the urinary findings are similar, 

 but with marked quantitative differences. Tyrosin cannot 

 usually be detected, at least by ordinary methods, being found 

 by Riess in but 7 of 36 cases of (human) phosphorus poison- 

 ing, and in but 4 of these was it abundant. Leucin is even 

 less frequently found. With experimental animals glycocoll 

 and other amino-acids have been found l in the urine, and they 

 could probably be found in acute hepatic atrophy if the same 

 delicate methods were employed. Wohlgemuth 2 has indeed 

 found glycocoll, alanin, and arginin in human urine after phos- 

 phorus poisoning. The small quantity of amino-acids in 

 phosphorus poisoning is probably due to the relative slowness 

 of the autolytic changes. On the other hand, the deficiency of 

 oxidation in phosphorus poisoning is shown by the abundant 

 elimination of organic acids, Riess having obtained as high as 

 4 to 6 grams of the zinc salt of paraladic acid from the urine 

 (per liter) in human cases, and its presence seems to be con- 

 stant. 



The I4ver. In the liver may be found an abundance of the 

 free amino-acids that have not yet escaped by diffusion, their 

 presence having been first detected by Frerichs microscopically. 

 Taylor 3 was able to isolate from a liver weighing 900 grams 

 0.35 gm. of leucin and 0.612 gm. aspartic acid, which probably 

 represent much less than the total amount present. Deutero- 

 albumose was also found, but no peptone, arginin, histidin, or 

 lysin, and glycogen was also absent. In another case that 

 appeared to be the result of chloroform intoxication, Taylor 4 

 obtained 4 grams of leucin, 2.2 grams of tyrosin, and 2.3 grams 

 of arginin nitrate. Wakeman 5 found that in phosphorus poi- 

 soning of dogs the liver shows a diminution of the hexone bases 

 as a whole, the arginin being especially reduced ; and Wohl- 

 gemuth 6 found arginin in the urine in phosphorus poisoning. 

 The lecithin of the liver is also decreased (Heffter 7 ), and the 

 increase in P 2 O 5 observed in the urine presumably comes partly 



1 Abderhalden and Barker, Zeit. physiol. Chem., 1904 (42), 524 ; Abderhal- 

 den and Bergell, ibid., 1903 (39), 464. 

 2 Zeit. physiol. Chem., 1905 (44), 74. 



3 Zeit. physiol. Chem., 1902 (34), 580 ; Jour. Med. Eesearch, 1902 (8), 424. 

 4 Univ. of Calif. Publications (Pathol.), 1904 (1), 43. 



5 Jour. Exper. Med., 1905 (7), 292. 



6 Zeit. physiol. Chem., 1905 (44), 74. 



7 Arch. exp. Path. u. Pharm., 1891 (28), 97. 



