502 CHEMICAL PATHOLOGY OF THE DUCTLESS GLANDS 



liver, 1 perhaps indirectly through some alteration in the action 

 of the pancreas. Experimental manipulation of the adrenals 

 causes glycosuria, while their removal is followed by a decrease 

 in the amount of sugar ; hence it is possible that both in health 

 and in disease the adrenals may have an important influence on 

 carbohydrate metabolism. Iwanoff 2 has found that adrenalin 

 increases the rate of discharge of sugar from the glycogen-rich 

 liver through which salt solution is being transfused, which 

 observation suggests that possibly adrenalin acts directly upon the 

 glycogen-splitting enzyme of the liver-cells. Underhill and 

 Clossen 3 suggest that adrenalin acts upon the liver through the 

 sympathetic nervous system ; they believe that adrenalin gly- 

 cosuria bears no relation to human diabetes. 



'See Wolownik-Charkow, Virchow's Arch., 1905 (180), 225. 

 2 Cent. f. PhysioL, 1905 (19), 891. 

 8 Loc. tit. 



