TREATMENT 43 



animals — not only those which shov^^ clinical symptoms, 

 but also any that may react to a dose of diagnostic 

 vaccine prepared from cultures of Johne's bacillus. As 

 to whether an attempt should be made to improve the 

 condition of an affected animal before it is sent to the 

 butcher, the circumstances of the case must decide. 

 Should, however, an attempt be made to cure an 

 affected animal, complete isolation should be insisted 

 on ; the dung, litter, etc., should be burnt, and a 

 separate pail kept for milking, if necessary. 



All the drugs that are usually employed as intestinal 

 astringents, as tonics, and as stimulants seem to have 

 been tried in Johne's disease, but in no case with 

 success. Miessner and Trapp record that tannoform, 

 creolin, starch gruels, iron, and various tonics, have all 

 given negative results in the hands of practitioners 

 who have brought cases of the disease to their notice 

 in the north-west of Germany. 



In England, dilute sulphuric acid, tobacco in the 

 form of balls, nitro-hydrochloric acid, cyllin, solutions 

 of copper sulphate, perchloride of iron, and other similar 

 reagents, combined with such foods and gruels as are 

 usually employed in cases of diarrhoea, have been given 

 without success. Astringents and tonics (combined 

 with good, easily digestible nitrogenous food, with 

 small quantities of roots or green food, and a restricted 

 allowance of water) may possibly be used in some 

 cases with temporary advantage, but there is no 

 certainty in the results. 



Curative vaccines, analogous to the curative tuber- 

 culins used in the human subject, can, of course, be 

 prepared. Indeed, in testing a badly affected animal 

 with various weak diagnostic vaccines, we have 

 noticed some considerable improvement in condition 

 after the administration of these reagents, and it is 



