110 



JOHNKS DISEASE 



part of this concentrated liquor was added to four 

 parts of a J per cent, aqueous solution of pure carbolic 

 acid. Of this reagent Bang gave the following doses : 



Animals over two years old 

 Animals one to two years old 

 Animals six months to one year old 



lo c.c. subcutaneously. 

 7-8 c.c. 

 5-6 c.c. 



It should be noted that the dose given (lo c.c. of a 

 I : 4 dilution) is about six times the dose of tuberculin 

 used (3-4 c.c. of a 1:9 dilution) when testing an adult 

 animal for tuberculosis. 



O. Bang found that in very advanced cases of the 

 disease a good reaction was not obtained with avian 

 tuberculin. In his report he gives the results of about 

 fifty tests, from which we have selected seven of the 

 most marked reactions. The temperatures are given 

 in degrees Centigrade in the following table : 



If the temperatures detailed above were the result of 

 tests with ordinary diagnostic tuberculin in tubercular 

 cattle, slaughter of all animals would be justified, as in 

 every case the maximum exceeds 105° F. (40*6° C), and 

 in some cases it reaches 106° F. (4ri° C). 



With the same vaccine O. Bang tested about 1,700 

 animals, mostly herds of tuberculosis-free Jersey cattle, 

 and he found that from 6 to 35 per cent, of adult cattle 

 reacted. Of those that reacted 34 animals (tuber- 



