162 



JOHNES DISEASE 



Fowls inoculated intravenously with Johne's bacillus 

 develop lesions more or less similar to those found in 

 rabbits after intravenous inoculation, but only a very 

 limited number of these animals have been tested. 



A Comparison with Other Acid-fast Bacilli. — C. C. 

 Twort and T. Craig have performed a considerable 

 number of experiments on rabbits with other members 

 of the acid-fast group, their object being to compare 

 the toxicity of these bacilli with that of Johne's 

 bacillus. The following bacilli were tested : 



1. Bacillus phlei (Moeller). 



2. Smegma bacillus (Moeller). 



3. Marpmann's bacillus from 



urine. 



4. Paratubercle bacillus (Binot). 



5. Mist bacillus (Moeller). 



6. Pseudoperlsucht (Moeller). 



7. Nasenschleim bacillus (Kar- 



linski). 



8. Duval's ''so-called" leprosy 



bacillus. 



9. Tobler I. 



10. Tobler II. 



11. Grassberger's bacillus. 



12. Fish tubercle bacillus (Du- 



bard). 



13. Grass bacillus (Moeller). 



Nearly a hundred animals were inoculated with 

 these bacilli, and a subsequent examination of the 

 organs was made. In the majority of rabbits B. phlei 

 was used ; only two or three animals were inoculated 

 with each of the remaining types of bacilli. 



It is upon the following points that the chief differ- 

 ences appear to rest : 



1. The general toxicity of the bacilli and the length 

 of time the animals survive after the inoculation. 



2. The power of the bacilli to cause a definite rise of 

 temperature. 



3. The excretion of the bacilli by the kidney, and the 

 production of nodules in this organ. 



4. The production of caseous nodules. 



5. The cultivation of the bacilli from the urine of the 

 inoculated animals. 



The bacilli detailed above may be divided into two 



