250 A MANUAL OF BACTERIOLOGY 



Other Organisms met with in Suppurative 

 and Septic Conditions 



Many other organisms may be met with in various suppurative 

 and septic processes, e.g. : 



a. The B. coli in cystitis and pyelitis, ischio-rectal abscess, 

 peritonitis associated with perforation and intestinal obstruction, 

 and puerperal fever (see Chapter X). 



&. The Diplococcus pneumonia in abscesses, empyema, arthritis, 

 meningitis, pericarditis, peritonitis, etc. (see Chapter XII). 



c. The B. typhosus in abscesses, cholecystitis, empyema, and 

 osteomyelitis (see Chapter X). 



d. The B. cedematis and B. Welchii in foul, gangrenous wounds 

 (see Chapter XIII). 



e. The B. tuberculosis and B. mallei (see Chapter IX). 



/. The actinomyces and streptothrix forms (see Chapter XV). 

 g. Blastomycetes, Sporotrichon (see Chapter XVI) and Hypho- 

 mycetes (see Chapter XVII). 



h. The Amoeba coli (see Chapter XVIII). 

 . Capsulated bacilli (see note, p. 258). 



Coley's Fluid 



This preparation consists of the toxins of the streptococcus of 

 erysipelas and the B. prodigiosus. It was devised by W. B. Coley, 

 of New York, as a cure for inoperable malignant tumours, particu- 

 larly sarcoma. The treatment is based on the undoubted fact that 

 malignant growths may decrease or even disappear completely 

 after an attack of erysipelas (p. 236). Originally prepared by grow- 

 ing a virulent streptococcus obtained from a fatal case of erysipelas 

 in bouillon for about ten days ; the culture is then inoculated 

 with the B. prodigiosus and the two are allowed to grow together 

 for another week or ten days. The culture is finally heated to from 

 58 to 60 C. for one hour, and a piece of thymol added to preserve 

 it. The fluid is now prepared by growing the organisms separately 

 and then mixing the two sterilised cultures in proper proportions. 



The fluid is injected subcutaneously in the vicinity of the tumour. 

 The primary dose recommended is J minim of the fluid. The 

 dose is gradually increased each day until there is a temperature 

 reaction of 103 to 104 F. 



Full particulars will be found in Coley's paper (Proc. Roy. Soc. 

 Med., vol. iii, 1909-10, Surg. Sect., p. 1). 



