BOVINE TUBERCULOSIS 315 



the neighbourhood of the digestive tract, which generally 

 retrogress and become calcareous. The bovine bacillus, 

 when introduced into rhesus monkeys or chimpanzees, 

 either by inoculation (even in so small a dose as 0-001 

 mgrm.) or by feeding, induces rapid generalised tuberculosis, 

 and, considering the close relation that exists between the 

 anthropoid apes and man, these results are of the highest 

 importance. In pigs, generalised progressive tuberculosis 

 is readily set up both by feeding with, and by the inocula- 

 tion of, bovine bacilli. Goats, dogs, and cats are relatively 

 less susceptible, but more or less tuberculous infection can 

 similarly be produced in them. On this part of the inves- 

 tigation the Commissioners remark that the bacillus of 

 bovine tuberculosis is not so constituted as to act on 

 bovine tissues only, and the fact that it can readily infect 

 the anthropoid apes, and, indeed, seems to produce this 

 result more readily than in the bovine body itself, has an 

 importance so obvious that it need not be dwelt on. The 

 viruses isolated from sixty cases of the disease in man 

 were also studied, and the results obtained show that they 

 may be divided into two groups, subsequently referred to 

 as Group I and Group II. The bacilli of Group I com- 

 prised fourteen viruses, one obtained from sputum, three 

 from tuberculous cervical glands, and ten from mesenteric 

 glands of primary abdominal tuberculosis in children. 

 The results produced by introducing these viruses into 

 animals are identical with those produced by the bovine 

 bacillus. The bacilli of Group II comprised forty viruses 

 obtained from various forms of human tuberculosis cer- 

 vical glands, mesenteric glands (8), lungs and bronchial 

 glands (10), joint and bone disease (9), testis, kidney, etc. 

 grow more luxuriantly in culture than those of Group I, 

 and inoculated into calves and rabbits do not produce 

 the generalised and fatal disease caused by the bovine 

 bacillus, but in rhesus monkeys and in the chimpanzee 



