PSEUDO-TUBERCULOSIS 331 



eye and having the appearance of an acute conjunctivitis. The 

 reaction soon passes off, generally without leaving ill effect. On 

 the whole the reaction appears to be fairly constant in tuberculous 

 individuals, but absence of reaction is not certain proof that the case 

 is not tuberculous. 1 



VII. Tuberculin for veterinary use. The dose of the various 

 preparations in the market varies according to their strength ; it 

 corresponds to 0-1 c.c. or 0-2 c.c. of Koch's original tuberculin. 



The appropriate dose is injected subcutaneously in the neck and 

 the reaction consists of a rise of temperature of from 1-5 to 6 F. 

 above the average normal, commencing 8-12 hours after injection 

 and lasting 12-14 hours, the temperature being taken at the 

 twentieth hour after injection, or, if it can be done, at frequent 

 intervals from the twelfth to the twentieth hour. The temperature 

 should be taken just before inoculation, and, if possible, morning 

 and evening for two or three days previous to inoculation. 



A healthy animal is unaffected by the injection, and if an animal 

 be extensively affected with tuberculosis the reaction may not be 

 given, or may be masked by the fever present. 



An ophthalmo-reaction may also be employed in cattle. 



Johne's disease, 2 a bovine enteritis, is due to an acid-fast bacillus 

 closely resembling the tubercle bacillus in morphology. It occurs 

 in scrapings of the affected mucous membrane of the bowel, and also 

 in sections of the intestinal wall. The Johne bacillus is inoculable 

 into the goat, but not into the guinea-pig or rabbit, and does not 

 grow on any of the ordinary laboratory media. Twort states that 

 it can be cultivated on the medium employed by him for growing 

 the leprosy bacillus (p. 335, and from the cultures a diagnostic) 

 vaccine may be prepared. 3 



Pseudo-Tuberculosis 



The term " pseudo- tuberculosis " (which is not a good 

 one, and should be discarded) has been applied to a number 

 of different conditions which have as a common character 

 the presence of tubercle-like nodules, but which are not 

 caused by the tubercle bacillus. Such are produced by 



1 See Brit. Med. Journ. and Lancet, 1907, vol. ii, and 1908, vol. i. 



2 See MacFadyean, Journ. Comp. Path, and Therap., vol. xx, 1907, 

 p. 48. 



3 Twort, Veterinary Record, Sept. 14, 1912. 



