332 A MANUAL OF BACTERIOLOGY 



certain parasitic worms, by Blastomycetes, Streptothrix and 

 Aspergillus, Protozoa, and by several bacteria. 



PfeifFer's Bacillus pseudo-tuberculosis produces nodular 

 deposits in the organ, accompanied by wasting, very like 

 true tuberculosis. The disease, however, runs a more 

 rapid course, death ensuing in the guinea-pigs two to three 

 weeks after inoculation. Guinea-pigs, rabbits, mice and 

 monkeys can be readily infected. The nodules consist of 

 masses of round cells which undergo necrosis and caseation. 

 The bacillus in the tissues is not readily stained, carbol- 

 methylene blue being the best solution, as it is not acid- 

 fast, nor does it stain by Gram's method. Morpho- 

 logically it is a small rod 1-2 /m in length, usually non- 

 motile, although, according to Klein, it possesses a single 

 flagellum or two flagella at one end. On gelatin it forms 

 a whitish growth without liquefaction, like that of the 

 colon bacillus, but confined to the needle-track. It pro- 

 duces alkali, forms no gas, and does not curdle milk. 

 Broth remains clear, with a whitish stringy flocculent 

 deposit. The bacillus grows readily and rapidly. 



MacConkey has found that the fermentation reactions 

 of this organism and of the plague bacillus are practically 

 identical (see " Plague," p. 395), and sterilised cultures of 

 either will protect against the other. 



Ovine caseous lymphadenitis, a disease of sheep simu- 

 lating tuberculosis, is due to a short pump bacillus with 

 rounded ends which stains well by Gram's method, and 

 grows best on blood-serum, on which it forms greyish 

 colonies. 1 



Much finds in the glands in Hodgkin's disease anti- 

 formin- resistant bodies, non-acid-fast, and similar to the 

 non-acid-fast tubercle bacilli which he has described. 



1 Sixteenth Ann. Rep. Bureau of Animal Indust. U.S.A., p. 638. 



