346 A MANUAL OF BACTERIOLOGY 



disease, which may also be contracted by some of the 

 Carnivora, such as the cat, lion, and tiger, by inoculation 

 or by feeding on diseased carcases. The rabbit, sheep, 

 and dog are but slightly susceptible, while cattle, swine, 

 and house mice are stated to be immune. Shattock 1 found 

 that the white mouse is somewhat susceptible, and suggests 

 that in all probability the house mouse is similarly so. 



In the horse the most constant seat of glanders lesions 

 is the lung, and McFadyeaii states that no case of glanders 

 with lesions elsewhere than in the lungs, and with these 

 organs unaffected, has ever been recorded. In nearly 

 every case of farcy, also, nodules are present in the lungs. 

 The lung lesions have the form of rounded, firm, or shotty 

 nodules. The number present is variable, rarely less than 

 a dozen ; exceptionally there are hundreds, fairly evenly 

 distributed throughout the lung tissue. The nodule 

 commences as a collection of polymorphonuclear leucocytes, 

 around which a zone of congestion is present. Later, the 

 alveolar walls undergo necrosis, and the leucocytes necrose 

 and disintegrate, but their chromatin persists as rounded 

 fragments which retain their affinity for nuclear stains 

 (chromatotaxis). The nodule may become surrounded 

 with a layer of thin fibrous tissue, between which and 

 the necrotic central area a zone of endothelioid cells with 

 giant- cells may be present (Plate XI. 6). 



The lesions of farcy are at the onset histologically 

 identical with the glanders nodule, but by the progressive 

 liquefaction of the tissues actual abscesses form. 



The lesions set up in an inoculated guinea-pig are very 

 characteristic, and can be used for diagnostic purposes. 

 With a very virulent culture, such as can be obtained by 

 several passages through a susceptible animal, a guinea-pig 

 may die in four or five days, and the post-mortem lesions 

 are slight, consisting of some caseation at the seat of 

 1 Trans. Path. Soc. Lond., vol. lix, 1898, p. 333. 



