BACILLUS TYPHOSUS 355 



and lungs in the pulmonary complications, and in the 

 urine. In the urine it is so frequently present that special 

 disinfection should be practised, more particularly during 

 convalescence, and in some cases it may be so abundant as 

 to produce a turbidity (typhoid bacilluria) and cystitis. 

 It is also pyogenic, and occurs (usually in pure culture) in 

 concurrent or post-typhoidal complications, e.g. empyema, 

 abscesses, osteomyelitis, suppurating ovarian cysts, 1 etc. 

 Clumps of bacilli in the gall-bladder have been suggested 

 as the nuclei of gall-stones, and the bacilli may be so 

 numerous in the gall-bladder and bile-ducts as to cause 

 cholecystitis and cholangitis. It is not easy to isolate the 

 organism from the stools, and plate cultivations on special 

 media must be employed, e.g. Conradi-Drigalski, malachite- 

 green, or brilliant- green, agar (see " Water "). 



Injected intraperitoneally into mice and guinea-pigs 

 the B. typhosus usually produces death, and the same 

 result follows from intravenous injections in rabbits, but 

 the pathogenic effects so obtained are not specific. By 

 continuous cultivation it loses its pathogenic properties. 

 Given by the mouth no result follows, and the same is 

 the experience of most observers who have fed animals on 

 typhoid stools ; a disease process analogous to typhoid 

 fever in man has rarely been induced experimentally. 

 Remlinger 2 states that by feeding young rabbits on 

 vegetables, cabbage, etc., soaked in water, to which had 

 been added some culture of the typhoid bacillus, he has 

 succeeded in inducing a condition resembling typhoid fever 

 in man. The charts which accompany the paper show 

 a typical rise of temperature, a period of pyrexia with 

 morning remission, followed by a typical fall of tempera- 

 ture. The animals suffered from diarrhoea, and their 

 blood gave the agglutination reaction. Post mortem, the 



1 Taylor, Jcurn. Obstet. and Gyncecol. Brit. Empire, Nov. 1907. 



2 Ann. de rinst. Pasteur, xi, 1897, p. 822. 



