PATHOLOGICAL CHANGES. 259 



There are two chief forms of leprosy. The one, usually 

 called the tubercular form lepra tuberosa or tiiberculosa 

 is characterised by the growth of granulation tissue in 

 a nodular form or as a diffuse infiltration in the skin, in 

 mucous membranes, etc., great disfigurement often result- 

 ing. In the other form, the anaesthetic, maculo - an- 



,v-, . 







FIG. 69. Section through leprous skin, showing the masses of cellular 

 granulation tissue in the cutis ; the dark points are clumps of bacilli deeply 

 stained. 



Paraffin section ; Ziehl-Neelsen stain. x 80. 



aesthetic of Hansen and Looft the outstanding changes 

 are in the nerves, with consequent anaesthesia, paralysis 

 of muscles, and trophic disturbances. 



In the tubercular form the disease usually starts with the 

 appearance of erythematous patches attended by a small 

 amount of fever, and these are followed by the development 

 of small nodular thickenings in the skin, especially of the 



