RHINOSCLEROMA. 281 



From these facts alone it is highly probable that they are 

 the active agents in the production of the lesions. Experi- 

 mental inoculation has thrown little light on the subject, 

 though one observer has described the production of 

 nodules on the conjunctive of guinea-pigs. The relation 

 of the rhinoscleroma organism to that of Friedlander is, 

 however, still a matter of doubt, and the matter has been 

 further complicated by the fact that a bacillus possessing 

 closely similar characters has been found to be very fre- 

 quently present in ozcena, and is often known as the 

 bacillus ozcence. The last-mentioned organism is said to 

 have more active fermentative powers. From what has 

 been stated it will be seen that a number of organisms 

 closely allied in their morphological characters, have been 

 found in the nasal cavity in healthy or diseased conditions. 

 From what we know, however, of other diseases, it is not 

 improbable that though presenting these close resemblances, 

 they may be distinct species, and may cause distinct patho- 

 logical conditions in man. The subject is one on which 

 more light is still required. 



