5*2 



HYDROPHOBIA. 



the cord used, and inject it under the skin by means of a 

 hypodermic syringe. The first injection was made with a 

 very attenuated virus, i.e., a cord fourteen days old. In 

 subsequent injections the strength of the virus was gradu- 

 ally increased, as shown in the table : 



The patient never manifested the slightest symptom of 

 hydrophobia. Other similarly favourable results followed ; 

 and this prophylactic treatment of the disease quickly 

 gained the confidence of the scientific world, which it still 

 maintains. (The principle is, of course, the same as in 

 artificially developing a high degree of active immunity 

 against a bacterial infection.) 



The only modification which the method has undergone, has been 

 in the treatment of serious cases, such as multiple bites from wolves, 

 extensive bites about the head, especially in children, cases which 

 come under treatment at a late period of the incubation stage, and 

 cases where the wounds have not cicatrised. In such cases the stages 

 of the treatment are condensed. Thus on the first day, say at 1 1 A.M. 

 and 4 P.M. and 9 P.M., cords of 12, 10, and 8 days respectively are 

 used ; on the second day, cords of 6, 4, and 2 days ; on the third 

 day, a cord of i day ; on the fourth day, cords of 8, 6, and 4 days ; on 

 the fifth, cords of 3 and 2 days ; on the sixth, cords of I day ; and so 

 on for 10 days. In each case the average dose is about 2 c.c. of the 

 emulsion. 



The success of the treatment has been very marked. The statistics 

 of the cases treated in Paris are published quarterly in the Annalcs 

 de I lustitnt Pasteur, and general summaries of the results of each year 

 are also prepared. As we have said, the ordinary mortality formerly 

 was 16 per cent of all persons bitten. During the ten years 1886-95, 



