240 VENOMOUS SNAKES AND THE PHENOMENA OF THEIR VENOMS 



In a later work Noguchi l prepared a pure crotalus antivenin with unmodi- 

 fied venom and used it to determine the specificity of antivenin in regard to 

 toxicity in vivo and haemolysis in vitro. The results are as shown in table 24. 



TABLE 24. 



CROTALUS TERRIFICUS ANTIVENIN. 



Brazil 2 immunized mules and horses with the venom of Crotalus terrificus, 

 or cascavel of Brazil. This antivenin neutralizes the toxic action of the 

 same venom as well as that of Lachesis jararacussu, but not that of Lachesis 

 lanceolatus, L. alternatus, and L. neuwiedii. 



ANCISTRODON PISCIVORUS ANTIVENIN. 



Noguchi 3 obtained pure antivenin for water-moccasin venom by treating 

 goat with modified venom followed by injections of unmodified venom. As 

 the supply of venom was insufficient he was unable to raise immunity to any 

 high degree. The antivenin which he got was, however, sufficiently strong 

 to determine the point in question. The results may be summarized in 

 table 25. 



TABLE 25. 



LACHESIS LANCEOLATUS ANTIVENIN. 4 



The antivenin prepared by Brazil by immunizing animals with the venom 

 of Lachesis lanceolatus has proved to be very effective against this venom and 

 also those of Lachesis alternatus and L. neuwiedii, but not at all so against 



1 Noguchi. Therapeutic experiments with anticrotalus and antimoccasin sera. Jour, of Exp. Med., 



1906, VIII, 614. 



1 Brazil. Contribution a I'&ude de 1'intoxication d'origine ophidienne. Paris, 1905. 

 8 Noguchi. Therapeutic experiments with anticrotalus and antimoccasin sera. Tour, of Exp. Med. 



1906, VIII, 614. 

 4 Brazil. Loc. cit. 



