BORIC ACID AND BORAX. 81 



There is no cold at this time and no febrile excitement, but a dull, 

 heavy feeling in the head. On the 8th there has been a considerable 

 diminution in the weight of the body, which is accredited to an excess 

 of exercise. On the 13th of June there is a decided recurrence of the 

 headache, attended with a feeling of weakness and nervousness, and 

 there are also pains in the stomach at times and some nausea; 2 grains 

 of quinine are administered. There is no febrile excitement. On th6 

 following days the headache disappears, but recurs again on the 16th 

 ,of June. There are no decided symptoms of headache on the following 

 da}^s, but at the end of the period, on June 21, there is a general feel- 

 ing of depression, though no particular variation from the normal can 

 be observed. 



During the after period there is a gradual improvement in feeling 

 and appetite, but nothing of a marked nature. On the last day of the 

 after period there is, however, a recurrence of the febrile excitement, 

 the temperature being 99.2 F. and the pulsations 78 and 100. 



The above data are not entirely convincing, but are of a nature to 

 show a certain tendency during the administration of the borax toward 

 a general feeling of unrest and discomfort. The frequent recurrence 

 of headache may not be clearly traced in every case to the adminis- 

 tration of borax, as in one instance at least it was attended with feb- 

 rile symptoms, doubtless due to an incipient cold. The nausea and 

 pains in the stomach, however, may be justly attributed to the admin- 

 istered preservative. Taken as a whole, therefore, the data seem to 

 indicate a marked tendency on the part of the administered preserva- 

 tive to produce a depressed and unfavorable condition of the body. 



SPECIAL SERIES. 



In two cases, namely, R. V. F. a and E. B. D., & a special series of 

 observations was made by reason of the poor health and general phys- 

 ical unfitness of the subjects for the regular conduct of the experi- 

 mental work. This was especially true of No. 13, who had pro- 

 nounced symptoms of pulmonary disturbance. In these cases the 

 analytical control of the metabolism was omitted for the most part 

 and attention directed rather to the general effect produced by the 

 exhibition of the preservative. Owing to the ill- health of the subjects 

 it was impracticable to determine to just what degree the symptoms 

 observed were to be ascribetl to the preservative administered. The 

 quantity of boric acid exhibited in these two cases did not exceed one- 

 . half gram per day, and in many cases, as will be seen by reference to 

 the schedule of administration of the special series, it was less. The 



Known as- No. 5 in Series I; later, when made a subject of special observations, 

 known as No. 13. 



& Known as No. 9 in Series II and as No. 14 in special series. 

 4242 No. 84, pt 104- 6 



