18 BELLADONNA FOLIA BELLADONNA RADIX. BENZOINUM. 



Compare Properties of powdered leaf and powdered root: 



Leaf: 



Appearance 

 Color ... 



Odor 

 Taste 



Root: 



Appearance 

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Odor 

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Assay of powdered Belladonna Root. In a flask place 15 Gm. Belladonna Root, 

 No. 60 powder ; add 50 mils chloroform and 100 mils ether ; shake vigorously, and then 

 let it stand about 10 minutes. Add 5 mils NH 4 OH, and agitate every 10 minutes for 

 the next 2 hours. Next add 15 mils distilled H^O; shake mixture well, let settle, then 

 decant 100 mils and filter it through purified cotton into a separatory funnel, adding 

 ether rinsings from graduate and expressed cotton. The alkaloids in solution may 

 now be extracted by repeated shakings out of the solution with weak sulphuric acid. 

 Place acid washings in a separator, add NH 4 OH until solution is plainly alkaline (lit- 

 mus) ; then repeatedly shake out with chloroform, which will again extract the alk- 

 aloids. Now exaporate all the chloroform from the washings, carefully dry, then dis- 

 solve the residue in exactly 5 mils ^ H2SO4 V. S., titrate the excess acid with J*. 

 KOH, V. S., using for indicator cochineal T. S. "Each mil of ^ H 2 SO4 V. S., con- 

 sumed corresponds to 28.92 mg. of the total alkaloids of Belladonna Root." 



What was the alkaloid percentage strength of your sample? 



\Vhat is the standard? 



The principal alkaloid of Belladonna is atropine (CiTH^oOsN). Belladonna is 

 used to diminish secretion, relax spasm of involuntary muscle, stimulate a depressed 

 nervous system, or produce dilatation of the pupil. 



Official Preparations. 



Extractum Belladonnas Foliorum, 1.2% strength. Dose, 0.015 Gm. 

 Tinctura Belladonnas Foliorum, 0.03% strength. Dose, 0.75 mil. 

 Unguentum Belladonnas, made from the extract; 10% of the extract. 

 Fluidextractum Belladonnas Radicis, 0.45% strength. Dose, 0.05 mil. 

 Linimentum Belladonnas, 95% Fluidextract. 

 Atropina. Dose, 0.0005 Gm. 

 Atropinse Sulphas. Dose, 0.0005 Gm. 



BENZOINUM. 



Benzoin is a balsamic resin obtained from Styrax Benzoin (Fam. Styracacea) , 

 trees of the Malay Peninsula and Dutch East Indies. 



Properties: 



Appearance 

 Color ... 



Odor 



Taste ... 



Solubility: 

 H,0 ... 



C 2 H OH 



KOH .. 



