70 FLUIDEXTRACTA. 



percolator, insert a cork, add enough alcohol so a stratum lies above the saturated 

 powder; cover tightly, and let maceration proceed for 48 hours. Then permit per- 

 colation to proceed, adding more alcohol until the drug is exhausted. The first 85 

 mils of the percolate are to be set aside as a reserved portion ; the balance is to be con- 

 centrated over a water bath, at a temperature not exceeding 60 C., until it is of a pasty 

 consistency. (If all the percolate had thus been concentrated, the resulting paste 

 would constitute the Extract.) Dissolve this paste in the reserved portion; then add 

 enough alcohol to make the total quantity equal 100 mils. 



Note : Appearance Color _ _ Taste 



Prepare the official Fluidextractum Ipecacuanhae, by "Type Process B," as fol- 

 lows: Prepare a preliminary menstruum of 10 mils dil. HC1, 20 mils alcohol, and 20 

 mils water; with this menstruum moisten 100 Gm. ipecac, in No. 60 powder, sufficiently 

 to render it evenly and distinctly damp ; place it loosely in a percolator, cover tightly, 

 and permit maceration to continue for six hours. Then pack firmly, add balance of 

 the menstruum, and when this has disappeared from the surface, gradually add 40% 

 alcohol, keeping a stratum constantly above the drug. When the liquid begins to escape 

 from the percolator, stopper, cover closely, and let maceration proceed for 48 hours. 

 Then allow the percolation to proceed slowly, gradually adding the 40% alcohol until 

 drug is exhausted. Reserve the first 80 mils of the percolate. Recover the alcohol 

 from the remainder, and then evaporate it to a soft extract at a temperature not ex- 

 ceeding 60 C. ; dissolve this paste in the reserved portion, and add enough 40% 

 alcohol to make the total equal 100 mils. (For method of assay, see U. S. P. IX, 188.) 



Note : Appearance - Color - Taste 



Prepare the official Fluidextractum Aconiti, "Type Process C," as follows: 

 Divide 100 Gm. aconite, in No. 40 powder, into three portions, in the ratio of 5:3:2. 

 Moisten the 50 Gm. portion with enough 75% alcohol to make it evenly and distinctly 

 damp, and to so maintain it after six hours maceration in a tightly covered container. 

 Then pack it loosely in a percolator, saturate it with alcohol, so that a stratum of the 

 menstruum covers the powder. Cork the lower orifice as soon as the liquid begins to 

 appear there, cover the percolator, and permit maceration to continue for 48 hours. 

 Then allow percolation to proceed, gradually adding more alcohol. Reserve the first 

 20 mils of the percolate, and collect 150 mils more in successive 3O-mil portions. 



Repeat the above process with the 30 Gm. aconite, using for the menstruum 

 adequate amounts of the 3O-mil portions in the order collected, or additional alcohol if 

 necessary. Reserve the first 30 mils of the percolate, adding it to the first 20 mils 

 reserved from the earlier percolation. Collect 80 more mils in successive 2O-mil 

 portions. 



Repeat this same process with the 2O-Gm. portion of aconite, using the preceding 

 2O-mil portions of percolate for menstruum. Collect 50 mils of the percolate from this 

 third lot, and add it to the first reserves of the other percolations, making 100 mils 

 finished product. (However, in Type C cases, where a definite assay is possible, the 

 procedure recommended in the U. S. P. is to collect but 42 mils of this third percolate, 

 to add this to the previous reserved portions, to then assay an aliquot part, and to finally 

 adjust the addition of further percolate, so that each mil of the finished Flnidextract 



