EXTRACTA. 73 



line to litmus, using NH 4 OH, and again extract the alkaloids by repeated shaking 

 out with chloroform. Now evaporate the chloroform solutions to dryness; treat the 

 alkaloids, contained in the residue, with 5 mils of ether; evaporate to dryness; treat 

 again with 5 mils ether, and again evaporate to dryness; then dissolve in exactly 5 

 mils tenth-normal H 2 SO4 V. S., and titrate the excess of acid with fiftieth-normal 

 KOH V. S., using cochineal T. S. as indicator. 



Each mil of titer consumed corresponds to 28.92 milligrams of the alkaloids of 

 belladonna leaves. 



I 'rof>cr ties of your Extract of Belladonna Leaves: 



Appearance 

 Color .. 



Odor 



Taste 



Weight of your Extract (to milligrams),.. 



Amount of titer used, 



Total alkaloids in 2 Gm. sample, 



Total alkaloids in your Extract, 



Amount of glucose to be added, 



Alkaloidal content of finished Extract, 



Prepare the official Powdered Extract of Rhubarb as follows: Moisten 100 Gm. 

 No. 40 powdered rhubarb with sufficient 8o ( /o alcohol; place it in a percolator; saturate 

 it so a stratum of the menstruum remains above ; macerate it for 48 hours. Then per- 

 colate it slowly, so as to obtain 300 mils. Distill off the alcohol, evaporate the residue, 

 at as low a temperature as possible, to a syrupy consistency. Place this in a shallow 

 dish, adding thereto rinsings from the still (using for this purpose 80% alcohol) ; 

 stirring frequently, evaporate this mixture to dryness, being careful the temperature 

 never exceeds 70 C. Weigh the dry extract ; add thereto 5 Gm. magnesium oxide, 

 and enough freshly dried starch to make the product weigh 50 Gm. Mix thoroughly, 

 reducing the mixture to a fine powder ; pass this through a No. 60 sieve, and transfer 

 it to a tightly stoppered bottle. 



Note : Appearance 

 Color .. 



Odor 

 Taste 



There are 25 official Extracts, the majority of which are powerful preparations. 

 They are made on a large scale by the manufacturers of pharmaceutical supplies, the 

 pilular extracts being extensively used in pill masses and in ointments. As they 

 rarely appear in other form their physical properties need not be studied at this time. 



