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CHLORAL HYDRATE. 



CHLORAL HYDRATE. 



1. Select 3 frogs of equal weight and condition. By anterior lymph sac adminis- 

 ter the following amounts of a 2% solution of Chloral Hydrate: 0.5 mil to frog No. I, 

 I mil to frog No. 2, 1.5 mil to frog No. 3. Keep the frogs moist, and record all varia- 

 tions observed, with their comparative times. Note symptoms the next day. 



2. Pith a frog of fair size. Administer by thigh lymph sac 0.5 mil 10% solution 

 Chloral Hydrate. Expose heart, connect with recording lever, and take continuous 

 record on a slow drum, keeping heart moist with normal saline. Once every 5 minutes 

 record a single contraction wave on a fast drum. Make comparative studies of your 

 findings. 



3. Take two cats of equal weight and condition. Secure normals of pulse and 

 respiration. To one administer by mouth 3.5 mils 10% sol. Chloral Hydrate; to the 

 other give the same dose plus 0.12 Gm. Caffeine. Keeping the cats quiet and con- 

 tented, watch the changes produced in the next 2 hours. 



4. Etherize a cat; adjust apparatus for recording respiration and circulation; 

 take temperature records also. To jugular vein attach a burette containing 0.5 Gm. x 

 kg. Chloral Hydrate in Locke's solution at 39 C. Obtain "normals"; stop ether, 

 and then allow solution to run from burette at the rate of i mg. every 3 seconds. What 

 evidences appear? 



5. Let two students who room in the same neighborhood study the effect of 

 Chloral Hydrate on man. Having secured the usual normals, let the subject take i 

 Gm. Chloral, and let the observer carefully note ensuing phenomena, keeping track of 

 the usual notations, including reflexes, onset of drowsiness, depth and character of 

 sleep, and its duration. 



6. In the hospital assignment, endeavor to ascertain if the presence in the body 

 of disease toxins necessitates a larger or smaller dose of Chloral for the securing of 

 a desired effect. 



7. From the literature tabulate the advantages and disadvantages as a soporific 

 of Chloral Hydrate and some of its congeners. 



EXPERIMENT No. i. 



