ACONITE. 145 



ACONITE. 



1. Into the anterior lymph sac of a frog inject 0.3 mil Tincture Aconite, diluted 

 with equal amount normal saline. Observe effect on the various reflexes. 



2. Expose the heart of a pithed frog ; secure normal tracings on both the slow and 

 fast drum. Into the thigh lymph sac inject 0.3 mil Tincture Aconite diluted. Con- 

 tinue tracings on slow drum, with an occasional cardiac curve on fast drum, noting 

 carefully any variations in the graph, or in the physical condition of the heart. 



3. Select two fasting rabbits, of equal weight and condition. Obtain normals of 

 respiration and heart-rate. Then to one administer by stomach o. i mil x kg. Tincture 

 Aconite ; to the other give hypodermically o. i mg. x kg. Aconitine. Continue regular 

 observations for several hours. 



4. Select a large healthy cat or rabbit. Etherize carefully ; connect with recording 

 apparatus, and secure usual normals, including temperature. Continuing the records, 

 slowly administer by vein a 20% dilution in warm Ringer's solution of Tincture 

 Aconite. Keep account of amount of drug used, and note gradual accumulation of 

 effect. Continue until animal dies. 



5. Place a drop of Tincture Aconite on the tongue, and note effect. 



6. On a student secure normals of respiration, pulse phenomena (rate, volume, 

 energy), blood-pressure, and temperature. Administer orally 0.6 mil Tincture 

 Aconite. Continue observations. 



7. Although the use of Aconite has become markedly restricted, it may occasion- 

 ally be studied in the wards of acute respiratory disorders. Particular attention 

 should be paid to -any registerable effect discoverable in relation to the circulation. 



8. Look up recent literature, and make a brief presentation of the arguments for 

 and against the use of Aconite. 



EXPERIMENT No. i. 

 Describe the effects of Aconite on a frog : 



EXPERIMENT No. 2. 

 Kymograph record of Aconite action on frog: 



