ANTIPYRIN. 149 



ANTIPYRIN. 



1. Determine the effects on respiration and the reflexes of a frog of o.i Gm. 

 Antipyrin injected into the anterior lymph sac. 



2. Determine effect produced by bathing a frog's heart with a i% solution of 

 Antipyrin. 



3. Determine the effects of Antipyrin on all the systems of a rabbit when 0.5 Gm. 

 x kg. are administered by mouth. 



4. Etherize a cat or rabbit. Connect with the several recording apparatus; 

 obtain the usual normals. With the jugular vein connect a burette containing a 10% 

 solution Antipyrin in warm Ringer's. Take continuous records while the solution 

 runs in at the rate of i mil every 2 minutes. Report your conclusions, with graphic 

 supporting evidence. 



5. Select a subject who is not anaemic, and obtain the usual normals, including 

 hemoglobin test and spectroscopic hsamic test. Administer 0.5 Gm. Antipyrin (or 

 0.75 Gm. Acetphenetidin). Continue taking the usual records. Two hours after the 

 drug has been taken secure another sample of blood for both haemoglobin and spectro- 

 scopic tests. In your report include your spectroscopic drawings. 



6. In the hospital, study circulation and temperature reactions of patients to 

 whom have been administered coal-tar preparations. 



7. What are the relative merits and demerits of the several coal-tar products used 

 in medicine? 



EXPERIMENT No. i. 

 Report of effects produced on frog: 



EXPERIMENT No. 2. 

 Kymograph record. Frog: 



