ALCOHOL. 157 



ALCOHOL. 



1. Pith the hrain of a frog. Obtain normal heart tracings; bathe heart with 20% 

 Alcohol, and note results. 



2. Obtain normal heart tracings from a pithed frog. Administer by stomach i 

 mil 20% Alcohol. Continue tracings on both slow and fast drums. 



3. Repeat Experiment No. 2, except to administer drug by thigh lymph sac. 



4. In the anterior lymph sac of one frog inject 2 mils 25% Alcohol. Give the 

 same dose by stomach to another frog of equal weight and condition. What results ? 

 Observe again next day. 



5. Having secured the normals of a rabbit, administer by stomach 5 mils x kg. 

 40% Alcohol, and note variations produced on all systems, including temperature. 

 When the animal becomes stupefied, inject hypodermically 0.3 Gm. Caffeine. 



6. Anaesthetize a cat or dog. Obtain the usual mechanical registrations of nor- 

 mals ; also note temperature. Into the jugular, vein, at the rate of i mil a minute, run 

 25% Alcohol, using warm Locke's solution for diluent, discontinuing the ether. Con- 

 tinue administration until animal dies. Endeavor to determine from your tracings at 

 what systemic point the drug exerts its toxic effect. Compute amount of Alcohol used. 



7. Select two subjects, one short and stout, the other tall and thin. Obtain nor- 

 mals of all the systems as usual. Test their reaction times to touch, hearing, and sight ; 

 test their mental activity with the antonym test, the imagery test, and the multiplica- 

 tion test; test strength with the grip dynamometer. Administer 20 mils French 

 brandy, well diluted. Continue observations for two hours, taking the extra tests 

 every half-hour. (This test is somewhat vitiated by the subject's anticipation. How 

 might this be remedied?) 



8. Since Alcohol has no advantageous utility in internal medicine, hospital obser- 

 vation will be available in the dipsomaniac wards only. Here study should be made of 

 the pharmacodynamic reactions which may be registerable in both acute and chronic 

 alcoholism. 



9. Summarize and criticise three recent articles on the use of Alcohol in medicine, 

 giving in each case your authority for position maintained. 



EXPERIMENT No. i. 

 Heart tracings, with local application of drug. Frog: 



