162 CANNABIS. 



CANNABIS. 



1. Determine what effect Cannabis has on the heart of a frog when the drug is 

 administered by stomach in the dose of 0.3 mil of the Tincture. 



2. Determine the effect on the reflexes of a frog when 0.3 mil Tincture Cannabis 

 is administered by lymph sac. 



3. Determine the effect of Cannabis on all the systems of a cat, dog, or rabbit, 

 when the drug is administered by stomach in doses of 0.3 mil x kg. 



4. Etherize a dog or large cat, and obtain usual registrations. Administer by 

 stomach 2 mils x kg. of an assayed Tincture of Cannabis. Stop the ether. Continue 

 records. Any pupil variations? 



5. Let a subject volunteer. Obtain the usual normals, and take record of his 

 reflexes, size of pupil, and sensations of pain and of tactual space-discrimination. Let 

 him describe a small simple picture at which he has gazed intently for 5 seconds. 

 Administer I mil Tincture Cannabis. Continue usual observations every 10 minutes. 

 At 4O-minute intervals test his powers of description. Test also the relative keenness 

 of pain and touch. 



Do not engage him in conversation, but if he wishes to talk, note character, con- 

 formity, and reasonableness of whatever he says. If he experiences subjective sensa- 

 tions, let him describe them. Keep a careful record of all phenomena, noting also the 

 advent of drowsiness, the time and character of sleep (omit blood-pressures now), 

 and the mental and physical condition of the subject on awakening. 



6. Interesting divergencies from the preceding experiment may be discovered by 

 having a subject smoke (and inhale the smoke) 0.065 Gm. powdered Cannabis. 



7. In the hospital assignment compare results obtained in Experiment No. 5 with 

 the efficiency of the drug, as well as its physiological actions, when it is used to quiet 

 cases of hysteria and nervous excitement. 



8. In the psychopathic ward study available manifestations of the "hashish" 

 habit. 



9. From recent literature summarize at least three articles discussing the use of 

 Cannabis in medicine. 



EXPERIMENT No. i. 

 Heart tracings from stomach administration. Frog: 



EXPERIMENT No. 2. 

 Report of effect on reflexes, drug by lymph sac. Frog: 



