224 COLCHICINE. 



IODIDES. 







The Iodides are the iodine salts of the alkali metals. 



Pharmacodynamics. 



Central Nervous System. Very large doses paralyze the depressor terminals in 

 the medulla. 



Secretory Glands. Urine increased ; some local action. 

 Absorption is very rapid from the mucosa. 

 Excretion is chiefly in the urine, 85% in a week. 



Symptoms. 



Therapeutic Dose. lodisin. 



No effect, unless patient has an Acute catarrh of nasopharynx 



idiosyncrasy, when iodism and accessory sinuses, 



may develop. Salivation and stomatitis. 



Erythemas and eczemas. 

 Possible oedema of larynx. 

 Therapeutics. 



The Iodides are of great value in the treatment of tertiary syphilis and post- 

 syphilitic manifestations; though their mode of action is obscure. 



Dosage. 



Potassii lodidum, o.i to 1.3 Gm. 

 Sodii lodidum, o.i to 1.3 Gm. 



COLCHICINE. 



Colchicine (CooH^sNOe == 396-23) is an alkaloid-like principle found in the 

 seeds and corm of Colchicum autumnale, a perennial plant of south-central Europe 

 and northern Africa. 



Pharmacodynamics. 



Central Nervous S Astern. Secondary exhaustion from the severe gastro-intes- 

 tinal irritation arising from large doses. 



Muscular system is unaffected. 



Respiration. Slowed and deepened; later becoming shallow; reflex. 



Heart is not affected until collapse impends. 



Blood-pressure not altered until late; then secondary. 



Alimentary Tract. The mucosa is intensely irritated by colchicum. This irrita- 

 tion rapidly induces a condition of systemic collapse similar to that produced in 

 cholera. 



Secretory Glands. Not affected directly. 



Metabolism. No conclusive data. 



Temperature. Not affected. 



Absorption is fairly rapid. 



Excretion. Uncertain. 



Local Action. Very irritating, producing redness and tickling. 



