PHOSPHORUS. 



ARSENIC. 



227 



PHOSPHORUS (continued). 



Symptoms. 



Medicinal Doses. 



No symptoms other than garlicky 

 eructations. 



Chronic Intoxication. 



Cachexia. 

 Slight jaundice. 

 Anaemia. 

 Albuminuria. 

 Chronic enteritis. 

 Necrosis of mandible. 

 Cirrhosis of stomach, liver and 

 kidney. 



Acute Toxic Doses. 



After several hours appear: 



Gastric pain. 



Nausea and garlicky eructations. 



Bilious vomiting. (Diarrhea.) 

 Apparent recovery, then after 

 several days, a recurrence of 

 above symptoms, plus 



Gastric and hepatic tenderness. 



Jaundice and bloody vomitus. 



Physical malaise; weak pulse. 



Lessened urine, casts, and blood. 



Subcutaneous hemorrhages. 



Exhaustion, collapse, coma, and 

 death. 



General fatty degeneration. 



Therapeutics. 



Phosphorus seems to be logically indicated in disturbances of bone development. 



Dosage. 



Pilulse Phosphori, i pill. (Each pill contains of phosphorus, 0.0006 Gm.) 



ARSENIC. 



Arsenic (As == 74-4) is a metal usually found in combination with cobalt, tin, 

 and copper ores. 



Pharmacodynamics. 



Central Nervous System. Peripheral neuritis and secondary cord degeneration 

 in chronic poisoning. In other cases there are "no certain indications of direct action." 



Muscular System. Secondary fatty degeneration. 



Respiration slackens in toxic doses from low blood-pressure. 



Heart weakens in toxic doses from direct action. 



Blood-pressure falls in toxic doses from direct action on muscle coat of arterioles, 

 especially of the splanchnic area. 



Alimentary Tract. Arsenic produces an irritation of the mucosa, extreme dila- 

 tation of the intestinal capillaries, and a specific fatty degeneration of the gastro-in- 

 testinal epithelium. 



Secretory Glands. Little affected. 



