'2* Harry C. Schmeisser. 



lymphocyte " of the hen's blood. * Allowing for flattening due to 

 pressure, these cells were round or oval, with round or oval nuclei, 

 mostly eccentric. The nuclear chromatin appeared granular or 

 reticular. The nucleus was not infrequently pale and vesicular with 

 one or more bright chromatin bodies. The cytoplasm was present as 

 a narrow rim, non-granular, and basophilic. Mitoses were common. 

 Between these cells was seen a delicate reticulum. In association with 

 these tumor masses were quite large collections of eosinophilic cells, 

 the majority showing a single, pale, round or oval, eccentric nucleus 

 and a relatively abundant cytoplasm, filled with large, round, elongated, 

 or spindle-shaped oxyphilic structures. They varied greatly in size 

 and shape. The lymphocytes and eosinophiles were occasionally 

 seen in the capillaries, but there was " certainly no definite increase 

 within the blood-vessels/' From the character of the cells, their rela- 

 tion to the portal spaces and absence of the lymphsemia, the condi- 

 tion was regarded by Butterfield as a proliferation of periportal 

 lymphadenoid tissue, and thought by him to merit the designation 

 " aleukaemic lymphadenoma." 



Mohler had under observation five similar cases showing lymphaemia 

 and the same lymphadenoid condition. Mohler's description of two 

 of his cases, as presented by Butterfield, is as follows: The process 

 showed a tendency to involve several organs. In one case the liver 

 and spleen were the principal seats, the lungs and intestine were 

 also involved. The liver was enlarged to twice the normal size, of 

 very light color and mottled. Throughout its surface and within 

 its parenchyma were whitish lymphomatous deposits of varying 

 diameters. A section shows the liver tissue only partly obliterated 

 as a result of a filling up of the interacinous capillaries with leucocytes. 

 The spleen was about the size of an ordinary blue plum. Each lung 

 contained a white spherical area, the size of a pea and composed 

 of hyperplastic lymphoid tissue, infiltrating white cells. In the wall 

 of the large intestine, involving the lymphadenoid tissue, were round, 

 slightly raised nodules. In the second case the changes were most 

 marked in the kidney and spleen. The liver, intestine and heart 

 were also involved. The kidneys were three or four times the normal 

 size and had macroscopically very much the same appearance as the 

 liver in the first case. The myocardium contained some small, whitish 



* Obviously the large mononuclear cell of the classification presented in 

 this paper. 



