4 Harry C. Schmeisser. 



He likewise examined the material from two additional cases of 

 lymphadenoid tumors of the fowl. One proved to be of the aleukaemic 

 type, as described by Butterfield ; the other was of the leukaemic form, 

 as described above. The histological picture, apart from the increase 

 of white cells in the blood-vessels in the one case, was identical in 

 both cases and also with that in the cases given above (Butterfield's, 

 Mohler^s and Warthin's). From these cases Warthin concludes, there- 

 fore, that there occurs in the common fowl a condition of disseminated 

 lymphocytoma, sometimes aleukaemic, at other times associated with 

 an increase of the white cells of the blood, this increase consisting in 

 the appearance of great numbers of cells of the large lymphocyte type 

 and apparently identical with the lymphoid cells of the tumor nodules. 

 He also regards the aleukaemic and leukaemic conditions as genetically 

 related, if not actually one and the same process in different stages. 

 Both conditions, he thinks, are in all respects analogous to the similar 

 ones existing in man. 



The preceding cases appear to be very similar to those reported by 

 later investigators and designated by them as splenomedullary in 

 type. 



Kon 4 in 1907, after the appearance of Warthin's article, reported 

 what he considers a true case of leukaemic disease of the chicken. 

 The gross and microscopical changes, which were studied and reported 

 in great detail, are in general identical with those of the cases above. 

 In addition, he found giant cells, though only a few, in the bone- 

 marrow, and mitoses in the basophiles as well as in the eosinophiles 

 in the kidneys. Because of the lack of smears, he determined the 

 ratio W/E and made differential counts from sectioned blood-vessels 

 of the liver. He found that the white cells, as compared with the 

 reds, were greatly increased and that the large mononuclear was the 

 predominating cell of the whites. Mitoses of this cell were observed. 

 The evidence given, he thinks, is sufficient to consider this a case of true 

 leukaemia. Because of the enormous swelling of the spleen and the 

 plentiful occurrence of the characteristic cell in the pulp of the normal 

 spleen and to a lesser degree in the normal bone-marrow, and in the 

 absence of lymphatic swelling and the occurrence of this cell in the nor- 

 mal lymph tissue, it seems to him most likely that this is a case of true 

 " splenic leukaemia." 



Soshestrenski," in May, 1908, reported a case of spontaneous 

 leukemia of the fowl, very similar to the case described by Kon. 



