18 Harry C. Schmeisser. 



masses of cells surrounded blood-vessels, both arteries and veins, infil- 

 trating the walls of the latter and filling the lumina of both. Within 

 the vessels the white blood cells were present in about equal proportion 

 with the red blood cells. Between these more focal accumulations the 

 myeloid cells had infiltrated in a more diffuse manner between the liver 

 columns, spreading them apart. It was usually difficult to demonstrate 

 the capillary wall. Hepatic cells in these locations did not suffer so 

 much. Some of the above-mentioned, circumscribed infiltrations 

 showed a coarse sclerosis. The same infiltrating cells were present as 

 in the cervical lymph-glands, with a prevalence of the large mononu- 

 clear, which was very rich in mitoses, and the mononuclear myelocyte 

 with eosinophilic granules. The two types of polymorphonuclear cells 

 and the premature red blood cells were present in fewer numbers. 



Spleen. Pulp diffusely infiltrated with closely packed leukaemic 

 cells, which crowded the reticulum, distended the blood-vessels and 

 separated and compressed the Malpighian bodies. The mononuclear 

 myelocyte with eosinophilic granules, although present, was scarce. 

 The large mononuclear, frequently showing mitoses, was the common 

 cell. 



Heart. The intramuscular capillaries, were moderately distended 

 with the large mononuclears and red blood cells, present in about equal 

 proportion. The former had also infiltrated between the muscle fibers. 

 The mononuclear myelocyte with eosinophilic granules was only occa- 

 sionally seen, both within and without the blood-vessels. 



Lungs. The intertubular blood-vessels, their branches which extend 

 into the capillary bed, and also the capillaries, were distended with 

 leukaemic blood, in which the large mononuclear seemed to exceed the 

 red blood cell. Mitoses were common. Infiltration of the tissue was 

 limited to two foci of myeloid cells. The one was composed principally 

 of the mononuclear myelocyte with eosinophilic granules and the large 

 mononuclear. Mitoses, especially of the first cell, were seen. Both 

 types of polymorphs were also present. The other focus was composed 

 exclusively of premature red blood cells, normoblasts and megaloblasts 

 showing mitoses. 



Kidneys. All the blood-vessels, from the largest to the capillaries of 

 the glomerular tuft, were distended with the characteristic leukaemic 

 blood. Throughout the section there was a diffuse infiltration of 

 myeloid cells, especially between the convoluted tubules. Here and 

 there were foci, in some of which the mononuclear myelocyte with 



