24: Harry C. Schmeisser. 



granular, (b') Same, with two masses of chromosomes in opposite ex- 

 tremes of the cell, (c') Same, with two purple nuclei, (d') Same, with 

 three purple nuclei. 



5. Mast Cell (Z) : As described in normal blood. 



6. Mononuclear myelocyte with eosinophilic granules (ra) : Eound 

 or slightly elliptical, diameter about length of normal normocyte or 

 longer. Nucleus, oval, pale blue with dense chromatin, eccentric. 

 Cytoplasm colorless with small and large, bright red granules, some 

 scattered over granules. 



Cytoplasmatic Masses without Nuclei (n) : Eound or slightly oval; 

 diameter varies, usually about width of normal normocyte. No nucleus. 

 Cytoplasm grayish-blue, sometimes with vacuoles. 



This, then, is the blood picture common to all the leukaemic cases. 

 The order of predominance of the white cells is typical of leukaemia, 

 differing from the normal, but agreeing with that of the spontaneous 

 case. The large mononuclear is present, by far, in greatest numbers. 

 The other cells of the normal blood are decreased. The polymorphonu- 

 clear with eosinophilic granules and the mast cell are very scarce. The 

 mononuclear myelocyte with eosinophilic granules, although not as 

 common as in the spontaneous case, can usually be demonstrated in 

 every leuksemic animal. 



The platelets are greatly increased in number. 



Differential Count, 300 Cells. 



Per cent. 



Polymorphonuclear with eosinophilic rods 6 



Polymorphonuclear with eosinophilic granules 



Lymphocyte 4 



Large mononuclear cell 86 



Mast cell 1 



Mononuclear myelocyte with eosinophilic granules ... 1 



Unclassified cells 2 



100 



AUTOPSY FINDINGS. 



The weight of the animal in every case was far below its weight before 

 injection.* Two lowest weights, at autopsy, were 675 and 897 gm. 



External Appearance. The jaundice was found at times to involve 

 the skin of the entire body.f The conjunctivas and buccal mucous mem- 



* Animals which remained negative invariably gained in weight, 

 f Probably this was more frequent but not recognized, except when very 

 grave, because of the normal yellow tint of the skin. 



