30 



Harry C. Schmeisser. 



TABLE 1 EXPERIMENTAL LEUKAEMIA. 



WEIGHTS, IN GRAMS OF BODY, OBGANS AND RELATION OF OBGANS TO BODY 



AT AUTOPSY. 



1 Not weighed. 

 * Very cedematous. 



3 Whole animal kept as a museum specimen. Illustrated, Fig. 5. 



4 Spontaneously cured. Not leukxmic at death. 



SUMMARY. 



In summarizing the essential points deduced by the simple trans- 

 mission of leukaemia by the injection of an organic emulsion, we shall 

 consider : 



1. Clinical History. After an incubation period, usually from five to 

 six weeks, the fowl suddenly becomes pale, jaundiced, emaciates rapidly, 

 loses weight and shows signs of extreme weakness, followed almost with- 

 out exception by death in one to two weeks. 



2. Blood. (a) The total number of white blood cells is greatly in- 

 creased, resulting in a proportion of one white to three red blood cells. 

 The differential count shows a marked increase and predominance of 

 the large mononuclear over the other white cells of the normal blood, 

 which have decreased. The mononuclear myelocyte with eosinophilic 

 granules is present in more or less numbers in practically every case. 

 Besides the normal-appearing large mononuclear, one sees many larger, 

 pale forms. In these cells, mitoses, in all stages, typical and atypical, 

 are common, (b) The total number of red blood cells is correspond- 

 ingly decreased, with a marked fall in the haemoglobin. They present 



