HKVIK'.V OF LITERATURE. k 2;) 



madder the Ixmes of the animal are found to he colored red after a 

 few days or weeks; but these experiments have not led to any posi- 

 tive conclusion in regard to the growth or metabolism of the boues. 

 I'nder pathological conditions, as rachitis and softening of the 

 bone-, an o-sein has been found which does not jrive any typical 

 gelatin on boiling with water. Otherwise pathological conditions 

 seem to all'ect chiefly the quantitative composition of the bones, and 

 especially the relationship between the organic and inorganic ^\\\>- 

 -tanee-. Attempts have been made to product 4 rachitis in animals 

 by the u-e of foods deficient in lime. From experiments on fully 

 developed animals contradictory results have been obtained. In 

 vounir, undeveloped animal- Vbil produced, by lack of lime salts 

 in the food, a change similar to rachitis. In full-thrown animals the 

 hones were changed afler a loin: time because of the lack of the lime 

 sail- in the food, but did not become -oft , on lv thinner (osteo-porosis). 

 The experiment- in which the lime -alts were removed from the bones 

 by t he addit ion of la< >d ha\ c led to no posit ive results 



(Ileit/mann. Heiflfl !>ai:in-kv . W. >ntrarv, has 



>hiwn by admini-ieri[r_r dilute siilpliurir acid or moiiosodium phos- 

 phate with the f-.od (pre-uppo-ini: that the food u'ave no alkaline 

 ash] to -herp and rabbit-, that the quantity of mineral matter in the 

 bone- miirht be dimini-hed. A i'.-u investigators are of the opinion 

 that in rachiti-. ifl in OSteomalacia, a solution of the lime salt- by 

 mean- OJ Thi- W*J -ted by the fact 



that \Veber and Schmidt' found lactic acid in the ey-t-like altered 

 born nee in osteomi Well-known inve-t i_Mtor- have 



di-pnted the poibility of the lime -.-dt- bein/ wa-hed from the hours 

 in OSteomalaCOSlfl by mean- ..f lactic acid. The recent investigations 



i he -obit ion of lime -alt- by 



lactic arid b alacia. lie has found that the normal relation- 



ship r.T < Ifl retained in all part- of th -malacia, 



which would n<>t be the ca-e if the ! -olved by an 



acid. The decrease in pho.-phate- occur- in the >ame (plant it at ive 

 relationship as the carbonate: and, according to Levy, in OSteo- 

 malacia the exhau.-tion of the bone take- plarc by decalcilicat ion, in 

 which one molecule of pho.-phate and calcium after the other is 

 removed. 



''Mi ,1873,3: 



51. 



* Yin-how's Archiv. ISS'J. 07 :901. 



. rhn. C.-ntrl.! . i- 590. 



s;i, j. t, 

 phynol. h.-m.. 189 



